{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:13:44Z","timestamp":1753892024381,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cavernous malformations are common vascular abnormalities of the central nervous system, but cavernous malformations of the cerebral aqueduct are rare. The choice of treatment is influenced by various factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Description<\/jats:title><jats:p>We report two cases of midbrain cavernous malformations. Both cases involved midbrain lesions obstructing the cerebral aqueduct, leading to obstructive hydrocephalus. The primary symptoms and complaints of the patients were related to hydrocephalus. Prior to surgery, patients underwent comprehensive imaging evaluations and received endoscopic third ventriculostomy rather than tumor resection. Both patients had favorable recoveries. We also reviewed the literature and discussed the choice of treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cavernous malformations are slow-progressing central nervous system lesions with a relatively benign natural course. When selecting a treatment strategy, clinicians should carefully consider the underlying cause of the patient\u2019s primary symptoms and the specific objectives of the surgery. Avoiding overly aggressive resection that fails to address the main symptoms and potentially causes irreversible damage is crucial.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1513254","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:45:21Z","timestamp":1738046721000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploration of treatment strategies for cerebral cavernous malformations: two case reports on non-resection treatment and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Yibo","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.75.5.0709","article-title":"Natural history of the cavernous angioma","volume":"75","author":"Robinson","year":"1991","journal-title":"J Neurosurg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.3.0422","article-title":"The natural history of familial cavernous malformations: results of an ongoing study","volume":"80","author":"Zabramski","year":"1994","journal-title":"J Neurosurg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.2.0237","article-title":"Seizure outcome after lesionectomy for cavernous malformations","volume":"83","author":"Cohen","year":"1995","journal-title":"J Neurosurg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320110205","article-title":"Familial cavernous angiomas: natural history and genetic study over a 5-year period","volume":"11","author":"Hayman","year":"1982","journal-title":"Am J Med Genet"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.3.453","article-title":"A gene responsible for cavernous malformations of the brain maps to chromosome 7q","volume":"4","author":"Dubovsky","year":"1995","journal-title":"Hum Mol Genet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.12.1851","article-title":"Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27","volume":"7","author":"Craig","year":"1998","journal-title":"Hum Mol Genet"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.08.024","article-title":"Characteristics of cavernomas of the brain and spine","volume":"19","author":"Kivelev","year":"2012","journal-title":"J Clin Neurosci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-014-1354-2","article-title":"Multiple cavernous malformations with hemorrhage of brain","volume":"81","author":"Prasad","year":"2014","journal-title":"Indian J Pediatr"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.04.189","article-title":"Multiple large-size cystic cerebral cavernomas","volume":"139","author":"Efe","year":"2020","journal-title":"World Neurosurg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/BF01405501","article-title":"Cavernous malformations of the brain stem. 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