{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:35Z","timestamp":1753891895029,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cardiac angiosarcoma, a rare and aggressive malignancy arising from endothelial cells, is difficult to diagnose owing to its nonspecific clinical symptoms and variable imaging features. Two cases of cardiac angiosarcoma (CA) are presented, each with different enhancement and metabolic patterns on imaging. Case 1: A 59-year-old man presented with chest tightness and lower extremity edema. Ultrasound and computed tomography (CT) imaging revealed a hypoechoic\/hypodense, non-enhancing mass with pericardial thickening in the right atrium. Positron emission tomography (PET) showed minimal uptake and, given that the patient had elevated D-dimer and fibrinogen levels, a thrombus was initially suspected. However, surgical intervention ultimately led to a diagnosis of CA. Case 2: A 27-year-old man presented with dyspnea and cough. Both ultrasound and CT imaging revealed a mass in the right atrium, with mid-to-low echogenic\/hypodense features, heterogeneous enhancement, and pericardial effusion, along with pericardial thickening. A PET scan showed a significant increase in radiotracer uptake within the mass, strongly suggestive of CA. Surgical intervention subsequently confirmed the diagnosis of CA. These two cases demonstrate the presence of distinct enhancement and metabolic patterns on imaging in primary CA and indicate the importance of considering a wide range of enhancement features and metabolic activities in the differential diagnosis of patients presenting with non-specific cardiac symptoms.<\/jats:p>","DOI":"10.3389\/fonc.2025.1515950","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:10:56Z","timestamp":1744603856000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Diversity of imaging in cardiac angiosarcoma: two cases with disparate enhancement and metabolic manifestations"],"prefix":"10.3389","volume":"15","author":[{"given":"Sinan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Cen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengtao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-1129","article-title":"The relationship between right atrial wall inflammation and poor prognosis of atrial fibrillation based on (18)F-FDG positron emission tomography\/computed tomography","volume":"14","author":"Wan","year":"2024","journal-title":"Quant Imaging Med Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s12872-023-03592-2","article-title":"Right atrial wall inflammation detected by (18)F-FDG PET\/CT may be significantly associated with persistent atrial fibrillation: a prospective case-control study","volume":"23","author":"Wan","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15221","article-title":"Cardiac angiosarcoma: A case report and review of the literature","volume":"38","author":"Luo","year":"2021","journal-title":"Echocardiography"},{"key":"B4","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/jcm12247764","article-title":"Surgically resected cardiac angiosarcoma: Survival analysis from the national cancer database","volume":"12","author":"Rahouma","year":"2023","journal-title":"J Clin Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231211772","article-title":"Cardiac angiosarcoma: a case report","volume":"51","author":"Farzin","year":"2023","journal-title":"J Int Med Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13060","article-title":"Echocardiographic features of cardiac angiosarcomas: the mayo clinic experience (1976-2013)","volume":"33","author":"Kupsky","year":"2016","journal-title":"Echocardiography"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211033261","article-title":"Primary cardiac angiosarcoma: a case report","volume":"49","author":"Fang","year":"2021","journal-title":"J Int Med Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3760\/cma.j.cn112151-20221019-00874","article-title":"Primary cardiac angiosarcoma: a clinicopathological and molecular genetic analysis of thirteen cases","volume":"52","author":"Liu","year":"2023","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"B9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jaccao.2020.05.009","article-title":"Cardiac tumors: JACC cardioOncology state-of-the-art review","volume":"2","author":"Tyebally","year":"2020","journal-title":"JACC CardioOncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/208929","article-title":"Papadopoulos CH and anastasiou-nana M. 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