{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:38:42Z","timestamp":1755225522953,"version":"3.43.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the safety and efficacy of CT-guided lung biopsy combined with microwave ablation (MWA) for solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This retrospective study included 37 post-radical surgery breast cancer patients with solitary suspected malignant pulmonary nodules, treated with CT-guided lung biopsy and MWA between January 2014 and December 2018. Institutional review board approval was obtained. Clinical outcomes and complications were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pathological results identified primary lung cancer in 5 patients (13.5%, 5\/37) and metastatic invasive ductal carcinoma (breast origin) in 30 patients (81.1%, 30\/37). Major complications included pneumothorax (n=8, 21.6%), chest pain (n=6, 16.2%), and hemoptysis (n=4, 10.8%). For metastatic cases, 2-, 3-, and 5-year survival rates were 86.2%, 58.3%, and 35.3%, respectively. The median progression-free survival after MWA was 35 months (range: 4\u201372; 95% CI: 24.53\u201346.48), and median overall survival was 44 months (95% CI: 32.55\u201355.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CT-guided lung biopsy combined with MWA is a safe and effective approach for managing solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1525114","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T12:51:41Z","timestamp":1755089501000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy"],"prefix":"10.3389","volume":"15","author":[{"given":"Chao","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peishun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qirong","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xusheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunling","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"B2","article-title":"Malignant tumors of the breast","volume-title":"Cancer. 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