{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:13:34Z","timestamp":1782170014046,"version":"3.54.5"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sebaceous nevus (SN) is a rare, benign, congenital tumor. There is limited information on its clinical features, familial influences, quality of life (QoL) impact, and treatment outcomes in Chinese patients. This study aimed to comprehensively examine these aspects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A questionnaire-based survey was conducted among patients with SN who visited the Department of Plastic Surgery at Shanghai Ninth People\u2019s Hospital between January 2018 and December 2023. Healthy control children were recruited using the \u2018best friends\u2019 principle to assess familial influences. QoL impact was measured using the Children\u2019s Dermatology Life Quality Index (CDLQI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis revealed that the severity of skin-related symptoms correlated with the extent of hyperplasia and lesion size. Maternal factors during pregnancy\u2014including medication use, secondhand smoke exposure, toxic chemical contact, and illness (notably COVID-19 infection)\u2014were significantly associated with a higher incidence of SN. Most patients reported a mild to moderate QoL impact. Surgical treatment demonstrated higher satisfaction rates compared to laser therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings suggest that hyperplasia and lesion size may predict symptom severity. The observed association between maternal COVID-19 infection and the occurrence of SN warrants further investigation. Surgical intervention appears to be an effective treatment, particularly for easily removable lesions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1529249","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:17:59Z","timestamp":1758773879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling new insights: a comprehensive questionnaire-based single-center study of sebaceous nevus"],"prefix":"10.3389","volume":"15","author":[{"given":"Jiamin","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.det.2021.09.006","article-title":"Epidermal nevi: what is new","volume":"40","author":"Waldman","year":"2022","journal-title":"Dermatol Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1992.tb00623.x","article-title":"Epidermal nevi and the epidermal nevus syndromes: a review of 233 cases","volume":"9","author":"Rogers","year":"1992","journal-title":"Pediatr Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1811-27","article-title":"Dermoscopic aspect of verrucous epidermal nevi: new findings","volume":"49","author":"Elmas","year":"2019","journal-title":"Turk J Med Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"296e","DOI":"10.1097\/PRS.0b013e3182589df2","article-title":"Giant nevus sebaceus: definition, surgical techniques, and rationale for treatment","volume":"130","author":"Chepla","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08849.x","article-title":"Great Ormond Street Hospital for Children Registry for congenital melanocytic naevi: prospective study 1988-2007. 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