{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:35:18Z","timestamp":1792478118450,"version":"4.5.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Macrophage polarization plays a crucial role in the development of various diseases. Simultaneously, macrophage polarization is intimately related to lipid metabolism. To assess the emerging trend of lipid metabolism during macrophage polarization, the present study was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, 472 publications that explored lipid metabolism during macrophage polarization were gathered using the Web of Science Core Collection database (WoSCC). The emerging trends were then described using CiteSpace.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2013 and 2023, 46 countries\/regions involving 268 institutions carried out studies in this field. The largest number of publications was found in China. Additionally, the most recent burst keywords included \u201cimmunometabolism\u201d, \u201cfoam cell formation\u201d, and \u201cpathway\u201d, which represented the current frontiers of research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The detailed analysis of publications pertaining to lipid metabolism during macrophage polarization reveals the current research status and identifies its hotspots.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1532862","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:30:46Z","timestamp":1750311046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Scientometric analysis of lipid metabolism in macrophage polarization: 2013-2023"],"prefix":"10.3389","volume":"15","author":[{"given":"Chenxiao","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.247215","article-title":"Research trends of macrophage polarization: A bibliometric analysis","volume":"131","author":"Gao","year":"2018","journal-title":"Chin Med J (Engl)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad072","article-title":"Breaking the macrophage code in atherosclerosis","volume":"119","author":"Monaco","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00769-0","article-title":"Macrophages in intestinal homeostasis and inflammatory bowel disease","volume":"20","author":"Hegarty","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087493","article-title":"Tumor-associated macrophage subsets: shaping polarization and targeting","volume":"24","author":"Zhang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/imr.2014.262.issue-1","article-title":"Macrophage phenotypes in atherosclerosis","volume":"262","author":"Colin","year":"2014","journal-title":"Immunol Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400983101","article-title":"Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria","volume":"101","author":"Verreck","year":"2004","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.809","article-title":"Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)","volume":"194","author":"Lee","year":"2001","journal-title":"J Exp Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602325","article-title":"The many faces of macrophage activation","volume":"73","author":"Mosser","year":"2003","journal-title":"J Leukoc Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/039463200401700209","article-title":"The expression of LEC\/CCL16, a powerful inflammatory chemokine, is upregulated in ulcerative colitis","volume":"17","author":"Pannellini","year":"2004","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512032","article-title":"Impact of lipid metabolism on macrophage polarization: implications for inflammation and tumor immunity","volume":"24","author":"Vassiliou","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for intellectual turning points: progressive knowledge domain visualization","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1517\/14712598.2012.674507","article-title":"Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace","volume":"12","author":"Chen","year":"2012","journal-title":"Expert Opin Biol Ther"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.v233.9","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306256","article-title":"Macrophage phenotype and function in different stages of atherosclerosis","volume":"118","author":"Tabas","year":"2016","journal-title":"Circ Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-2994","article-title":"Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages","volume":"80","author":"Su","year":"2020","journal-title":"Cancer Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1111\/jgh.v35.11","article-title":"Regulation of lipid-induced macrophage polarization through modulating peroxisome proliferator-activated receptor-gamma activity affects hepatic lipid metabolism via a Toll-like receptor 4\/NF-\u03baB signaling pathway","volume":"35","author":"Wu","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.618501","article-title":"Arachidonic acid metabolism controls macrophage alternative activation through regulating oxidative phosphorylation in PPAR\u03b3 Dependent manner","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"213116","DOI":"10.1016\/j.bioadv.2022.213116","article-title":"Maresin 1 enhances osteogenic potential of mesenchymal stem cells by modulating macrophage peroxisome proliferator-activated receptor-\u03b3-mediated inflammation resolution","volume":"141","author":"Yao","year":"2022","journal-title":"Biomater Adv"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.11.006","article-title":"Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPAR\u03b3 dependent mechanisms","volume":"1862","author":"Assunc\u00e3o","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.v25.12","article-title":"Prostaglandin E(3) attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization","volume":"25","author":"Cui","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"102452","DOI":"10.1016\/j.redox.2022.102452","article-title":"Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS\/p38 MAPK\/DGAT1 pathway and inhibiting M2 macrophage polarization","volume":"56","author":"Liu","year":"2022","journal-title":"Redox Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005940","article-title":"Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models","volume":"11","author":"Kansal","year":"2023","journal-title":"J Immunother Cancer"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.011","article-title":"Metabolic biomarkers significantly enhance the prediction of HBV-related ACLF occurrence and outcomes","volume":"79","author":"Zhang","year":"2023","journal-title":"J Hepatol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1532862\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:30:47Z","timestamp":1750311047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1532862\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":30,"alternative-id":["10.3389\/fonc.2025.1532862"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1532862","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"article-number":"1532862"}}