{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:31:26Z","timestamp":1785893486302,"version":"3.56.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>CRLF2<\/jats:italic> abnormalities are prevalent in Hispanics from the U.S. and Mexican children with pre-B acute lymphoblastic leukemia (ALL). This trait is associated with unfavorable prognosis. Furthermore, SNPs rs3824662 and rs3781093 in <jats:italic>GATA3<\/jats:italic> have been associated with an increased risk of pre-B ALL. In particular, rs3824662 is associated with <jats:italic>CRLF2<\/jats:italic>-ALL, with a higher prevalence in Hispanic patients. Additionally, rs3824662 is associated with adipogenesis, since Hispanic patients have a high prevalence of obesity and overweight, it has been suggested that obesity predisposes to <jats:italic>CRLF2-<\/jats:italic>ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we evaluated rs3824662 and rs3781093 as predisposition markers for pre-B ALL in Mexican children using Taqman probes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both risk alleles were found to be associated with susceptibility to pre-B ALL, predisposition to <jats:italic>CRLF2<\/jats:italic>-ALL, overweight status, and overall survival. The risk alleles of both SNPs in Mexican patients were among the most frequent compared with other non-Amerindian populations. SNP rs3824662 and rs3781093 were informative for our patients. Analysis of nutritional status indicated that <jats:italic>GATA3<\/jats:italic> alleles may impact overweight status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Further studies on the relationship between nutritional status and <jats:italic>GATA3<\/jats:italic>, as well as analysis of other Amerindian ALL populations, are recommended.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1533756","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:31:24Z","timestamp":1747045884000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican 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