{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:34:25Z","timestamp":1788194065507,"version":"build-2803163510"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"Background<\/jats:title>Reducing the incidence rate of persistent\/recurrent HPT after surgery is the key to the treatment of PHPT. The pitfalls of preoperative, intraoperative, and postoperative management in PHPT patients and their potential impact on surgical strategies need to be comprehensively investigated.<\/jats:p><\/jats:sec>Methods<\/jats:title>The demographic, biochemical, radiological results and other clinical data of the enrolled 112 patients with primary hyperparathyroidism undergoing surgical treatment were obtained from our database in this retrospective cohort study. One-way analysis of variance was used for normally distributed variables, and Kruskal-Wallis H test was used for non-normally distributed variables. Pearson\u2019s chi-square test or Fisher\u2019s exact test was used for categorical variables, as appropriate.<\/jats:p><\/jats:sec>Results<\/jats:title>The patients were divided into parathyroid adenoma group and atypical parathyroid tumor + parathyroid carcinoma group. The serum calcium levels, serum PTH levels in the APT+PC group were higher than those with benign lesions, but there was some overlap; and the clinical data showed no specificity in the differentiation of benign and malignant parathyroid tumors. A more significant finding in this cohort was that the tumor size was significantly larger in persistent\/recurrent HPT group than in non-persistent\/recurrent group (30.0 \u00b1 12.6\u00a0mm vs.19.1\u00b1 8.3\u00a0mm, p &lt; 0.01).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In PHPT, there are pitfalls in preoperative, intraoperative, and postoperative management of parathyroid tumors, which affect the choice of surgical strategies. It is prudent to utilize the tumor-free margin En bloc resection in a variety of parathyroid neoplasms, in order to seek the chance of cure and avoid reoperation as much as possible.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1535089","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:30:59Z","timestamp":1747287059000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of management traps on surgical strategies in parathyroid benign and malignant tumors-related PHPT: a retrospective cohort study"],"prefix":"10.3389","volume":"15","author":[{"given":"Guang-wen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bone.2014.12.003","article-title":"Secular trends in the incidence of primary hyperparathyroidism over five decades (1965-2010)","volume":"73","author":"Griebeler","year":"2015","journal-title":"Bone"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4673-2","article-title":"Parathyroid carcinoma: is it time for change","volume":"22","author":"Schneider","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12022-022-09709-1","article-title":"Overview of the 2022 WHO classification of parathyroid tumors","volume":"33","author":"Erickson","year":"2022","journal-title":"Endocr Pathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/PAP.0000000000000379","article-title":"Advances and updates in parathyroid pathology","volume":"30","author":"Gokozan","year":"2023","journal-title":"Adv Anat Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4689","article-title":"Surgical aspects of primary hyperparathyroidism","volume":"37","author":"Perrier","year":"2022","journal-title":"J Bone Miner Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196297","article-title":"Parathyroid retrospective analysis of neoplasms incidence (pTRANI study): an italian multicenter study on parathyroid carcinoma and atypical parathyroid tumour","volume":"12","author":"Gurrado","year":"2023","journal-title":"J Clin Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1027598","article-title":"Clinical and genetic analysis of atypical parathyroid adenoma compared with parathyroid carcinoma and benign lesions in a Chinese cohort","volume":"14","author":"Chen","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The american association of endocrine surgeons guidelines for definitive management of primary hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/cen.13055","article-title":"Preoperative diagnosis and prognosis in 40 Parathyroid Carcinoma Patients","volume":"85","author":"Xue","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102012","article-title":"Parathyroid cancer: An update","volume":"86","author":"Rodrigo","year":"2020","journal-title":"Cancer Treat Rev"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae108","article-title":"Consensus statement of the European Society of Endocrine Surgeons (ESES) on advanced parathyroid cancer: definitions and management","volume":"111","author":"Makay","year":"2024","journal-title":"Br J Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.11.001","article-title":"Parathyromatosis: a rare yet problematic etiology of recurrent and persistent hyperparathyroidism","volume":"61","author":"Hage","year":"2012","journal-title":"Metabolism"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-7404(99)00037-7","article-title":"Parathyroid cancer: biology and management","volume":"8","author":"Koea","year":"1999","journal-title":"Surg Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22599","article-title":"Trends in the incidence and treatment of parathyroid cancer in the United States","volume":"109","author":"Lee","year":"2007","journal-title":"Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.surg.2014.08.069","article-title":"Parathyroid carcinoma in more than 1,000 patients: A population-level analysis","volume":"156","author":"Sadler","year":"2014","journal-title":"Surgery"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1535089\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:30:59Z","timestamp":1747287059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1535089\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":15,"alternative-id":["10.3389\/fonc.2025.1535089"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1535089","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"article-number":"1535089"}}