{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:10:47Z","timestamp":1785553847068,"version":"3.56.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this case report is to explore the efficacy of comprehensive treatment of anal melanoma and to provide reference for the treatment of anal melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A rare case of anorectal melanoma was collected. After local excision, the patient was treated with a combination of the anti-vascular survival drug bevacizumab, anti-PD-1 immunotherapy and other treatments, and the patient\u2019s prognosis and survival were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 61-year-old male was admitted to the hospital with complaints of anal prolapse and a mass appearing after defecation, accompanied by intermittent bloody stool for one week. He was initially diagnosed with mixed hemorrhoids, and a hemorrhoidectomy was performed. Postoperative pathology confirmed malignant melanoma with negative surgical margins, leading to a clinical diagnosis of AM. Following local excision surgery, the patient underwent targeted therapy with bevacizumab, anti-PD-1 immunotherapy and other treatments. After nearly three years of follow-up, the patient remained in good condition and while follow-up CT and MRI revealed some enlarged lymph nodes, there were no symptoms or signs of systemic metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of local resection of the primary lesion with bevacizumab targeted therapy and anti-PD-1 immunotherapy is feasible and can substantially improve the survival time of patients with AM.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1535376","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:10:38Z","timestamp":1750911038000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful multimodality treatment of anorectal melanoma after wide local excision: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhao","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Zongjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chunlai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Lihua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hexue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrab107","article-title":"Surgical treatment of anorectal melanoma: a systematic review and meta-analysis","volume":"5","author":"Jutten","year":"2021","journal-title":"BJS Open"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.1633","article-title":"Melanoma of the rectum: a rare entity","volume":"14","author":"van Schaik","year":"2008","journal-title":"World J Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002770","article-title":"Incidence, surgical treatment, and prognosis of anorectal melanoma from 1973 to 2011: A population-based SEER analysis","volume":"95","author":"Chen","year":"2016","journal-title":"Med (Baltimore)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.01.022","article-title":"Wide local excision or abdominoperineal resection as the initial treatment for anorectal melanoma","volume":"189","author":"Droesch","year":"2005","journal-title":"Am J Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0793-z","article-title":"Effect of misdiagnosis on the prognosis of anorectal Malignant melanoma","volume":"136","author":"Zhang","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000001003","article-title":"Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma","volume":"34","author":"Paolino","year":"2024","journal-title":"Melanoma Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2021.101558","article-title":"Survival following surgical treatment for anorectal melanoma seems similar for local excision and extensive resection regardless of nodal involvement","volume":"37","author":"Jutten","year":"2021","journal-title":"Surg Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-018-0791-1","article-title":"Anorectal Malignant melanoma-defining the optimal surgical treatment and prognostic factors","volume":"9","author":"Nusrath","year":"2018","journal-title":"Indian J Surg Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s11912-019-0799-x","article-title":"Changes in the 8th edition of the American joint committee on cancer (AJCC) staging of head and neck cancer: rationale and implications","volume":"21","author":"Zanoni","year":"2019","journal-title":"Curr Oncol Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02051925","article-title":"Anorectal Malignant melanoma in Sweden. 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