{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:23:19Z","timestamp":1783020199988,"version":"3.54.6"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Breast cancer has become the second most common cancer after lung cancer. Patients may present with skin manifestations at the time of initial diagnosis, while erysipel-like carcinoma typically appears later, following initial treatment. This delay increases the risk of misdiagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>The patient was a 51-year-old female. A modified radical mastectomy for left breast carcinoma (pT2N3M0, stage IIIC; tumor size 4.6 cm \u00d7 4.5 cm \u00d7 1.6 cm, 14\/21 axillary lymph nodes involved), HER2-positive type, was performed on April 21, 2021. In April 2024 (three years post-surgery), the patient developed unexplained redness and swelling in the skin of the left upper limb, accompanied by increased skin temperature. This was misdiagnosed as erysipelas of the upper limb. After one week of antibiotic treatment, the redness and swelling slightly subsided. In May 2024, the patient experienced dizziness and headaches without any obvious cause. Enhanced cranial MRI revealed multiple brain metastases, with possible lymph node metastasis in the left cervical region. The patient underwent whole-brain radiotherapy. During radiotherapy, erysipelas-like rashes developed on the left chest wall, upper limb, and right breast skin. In June 2024, a skin biopsy of the chest wall confirmed cutaneous metastasis. Following systemic anti-tumor treatment, both the skin and brain metastasis improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pathological biopsy should be emphasized when breast cancer patients develop localized rashes. Understanding the unique inflammatory manifestations of cutaneous metastasis is crucial for breast oncologists to enable early diagnosis, timely treatment, and improved overall survival.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1535421","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T04:10:13Z","timestamp":1752466213000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Advanced breast invasive ductal carcinoma with erysipeloid cutaneous metastasis misdiagnosed as erysipelas"],"prefix":"10.3389","volume":"15","author":[{"given":"Weiju","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21863","article-title":"Breast cancer statistics","volume":"74","author":"Giaquinto","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13058-023-01750-0","article-title":"Effect of histological breast cancer subtypes invasivelobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials","volume":"25","author":"Dayan","year":"2023","journal-title":"Breast Cancer Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2967\/jnmt.123.266035","article-title":"Gastric metastasis from invasive lobular breast cancer, resembling primary gastric cancer","volume":"52","author":"Dilawar","year":"2024","journal-title":"J Nucl Med Technol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.37029\/jcas.v6i1.307","article-title":"Skin metastasis in breast cancer patients; a case series","volume":"6","author":"Rehman","year":"2020","journal-title":"J Cancer Allied Spec"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.12144\/zgmfskin202211803","article-title":"Clinical and histopathological analysis of 62 cases of cutaneous metastatic carcinoma","volume":"38","author":"Lian","year":"2022","journal-title":"Chin J Lepr Skin Dis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2019.10.004","article-title":"Cutaneous metastases: A great imitator","volume":"38","author":"Jaros","year":"2020","journal-title":"Clin Dermatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19361","article-title":"Clinical characteristics and survival analysis of cutaneous metastases in a single tertiary centre in Korea","volume":"37","author":"Shin","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-023-07230-5","article-title":"Investigating the role of tumour-to-skin proximity in predicting nodal metastasis in breast cancer","volume":"205","author":"Sivakanthan","year":"2024","journal-title":"Breast Cancer Res Treat"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2024.10.008","article-title":"Carcinoma erysipeloides, a case-report and review of the sixty-nine cases in the literature","volume":"369","author":"Ero\u011flu","year":"2025","journal-title":"Am J Med Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.11786\/sypfbxzz.1674-1293.20200403","article-title":"Clinical and literature analysis of erysipelas skin metastases","volume":"13","author":"Wenlin","year":"2020","journal-title":"J Pract Dermatol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215416","article-title":"Clinical, pathological, and molecular features of breast carcinoma cutaneous metastasis","volume":"13","author":"Gonz\u00e1lezmart\u00ednez","year":"2021","journal-title":"Cancers Basel"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000609","article-title":"Molecular prediction of metastasis in cutaneous squamous cell carcinoma","volume":"32","author":"Mulvaney","year":"2020","journal-title":"Curr Opin Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.12114\/j.issn.1007-9572.2020.00.164","article-title":"Analysis of the diagnostic process of a case of breast cancer with skin metastasis misdiagnosed as sebaceous gland cyst with infection","volume":"23","author":"Xiaobin","year":"2020","journal-title":"Chin Gen Pract"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8852459","article-title":"Cutaneous metastasis in the setting of both colon and breast primary Malignancies","volume":"2020","author":"Junak","year":"2020","journal-title":"Case Rep Gastrointest Med"},{"key":"B16","article-title":"A sinister rash in a lady with breast Malignancy","volume":"76","author":"Tan","year":"2021","journal-title":"Med J Malaysia"},{"key":"B17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3892\/mco.2022.2543","article-title":"Skin metastases from gastric cancer, a rare entity masquerading as erysipelas: A case report","volume":"16","author":"Pliakou","year":"2022","journal-title":"Mol Clin Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.12865\/CHSJ.50.03.12","article-title":"Cutaneous metastases of signet-ring cell gastric carcinoma: A case report","volume":"50","author":"Kurmus","year":"2024","journal-title":"Curr Health Sci J"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23445","article-title":"Carcinoma erysipeloides with clinical and dermatoscopic features: an overlooked clinical manifestation of breast cancer","volume":"14","author":"Alexis","year":"2022","journal-title":"Cureus"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19962","article-title":"Dermatoscopic patterns of cutaneous metastases: A multicentre cross-sectional study of the International Dermoscopy Society","volume":"38","author":"Tiodorovic","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.16073\/j.cnki.cjcpt.2021.17.09","article-title":"Characteristics and prognosis of skin metastasis of female breast cancer","volume":"28","author":"Xinmiao","year":"2021","journal-title":"Chin J Cancer Prev Treat"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1535421\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T04:10:19Z","timestamp":1752466219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1535421\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":21,"alternative-id":["10.3389\/fonc.2025.1535421"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1535421","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"article-number":"1535421"}}