{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:52:20Z","timestamp":1773953540709,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Benign notochord cell tumor (BNCT) in the bilateral lungs is exceedingly rare. This report details a case of a male patient diagnosed with primary bilateral lung BNCTs and concurrent sacral tumors. As part of a routine health check-up, a chest CT revealed suspicious nodules in both lungs. We performed a thoracoscopic wedge resection of the nodules on him. The postoperative pathological findings combined with CT and clinical manifestations confirmed BNCT. Post-operatively, considering that BNCT commonly occurs in the axial skeleton, we conducted an examination of the spine. Spinal CT and MRI revealed suspicious sacral lesions in the S3 to S5 vertebrae, necessitating further investigation and continuous follow-up monitoring. The simultaneous occurrence of primary multifocal pulmonary BNCTs coexisting with sacral tumors has never been reported before. Fully taking into account potential associations with other diseases, careful follow-up and a comprehensive diagnostic approach are essential for patients with pulmonary nodules.<\/jats:p>","DOI":"10.3389\/fonc.2025.1537943","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:25:30Z","timestamp":1747805130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Multiple primary bilateral lung benign notochord cell tumors combined with sacral tumors"],"prefix":"10.3389","volume":"15","author":[{"given":"Minjia","family":"Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14265","article-title":"Updates from the 2020 world health organization classification of soft tissue and bone tumours","volume":"78","author":"Anderson","year":"2021","journal-title":"Histopathology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.24287","article-title":"Evaluating the patient with a pulmonary nodule: A review","volume":"327","author":"Mazzone","year":"2022","journal-title":"JAMA"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/231652","article-title":"A case of pulmonary hamartoma showing rapid growth","volume":"2013","author":"Itoga","year":"2013","journal-title":"Case Rep Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2017.1244","article-title":"Solitary pulmonary caseating granulomas: A 5-year retrospective single-center analysis","volume":"6","author":"Watanabe","year":"2017","journal-title":"Mol Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.28920\/dhm49.4.306-310","article-title":"A case of L\u00f6fgren\u2019s syndrome confused with decompression sickness","volume":"49","author":"Razdan","year":"2019","journal-title":"Diving Hyperb Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.4103\/1817-1737.43082","article-title":"Diagnosis of peripheral pulmonary carcinoid tumor using endobronchial ultrasound","volume":"3","author":"Steinfort","year":"2008","journal-title":"Ann Thoracic Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e14218","DOI":"10.7759\/cureus.14218","article-title":"Isolated solitary lung nodule in a patient with idiopathic pulmonary fibrosis and concomitant prostate cancer: A challenging diagnosis","volume":"13","author":"Tarabaih","year":"2021","journal-title":"Cureus"},{"key":"B8","article-title":"Well differentiated liposarcoma of a lung: report of a case","volume":"77","author":"Yamamoto","year":"2024","journal-title":"Kyobu Geka"},{"key":"B9","first-page":"793","article-title":"Benign and malignant chordomas: a clinico-anatomical study of twenty-two cases","volume":"28","author":"Congdon","year":"1952","journal-title":"Am J Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/00000478-200303000-00015","article-title":"Giant vertebral notochordal rest: A lesion distinct from chordoma: discussion of an evolving concept","volume":"27","author":"Kyriakos","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1007\/s002560100422","article-title":"Giant notochordal hamartoma of intraosseous origin: a newly reported benign entity to be distinguished from chordoma. 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