{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:02:31Z","timestamp":1751601751301,"version":"3.41.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Myxofibrosarcoma (MFS) is an exceedingly rare malignant neoplasm of fibroblastic origin, characterized by its low clinical incidence. It primarily manifests in the extremities and the posterior trunk, with involvement of the head and neck or abdominal wall being notably uncommon. Epidemiological estimates place their annual incidence at fewer than 0.1 cases per 100,000 population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>This case report describes the diagnostic and therapeutic management of an elderly male patient presenting with myxofibrosarcoma located in the right inguinal region, with confirmed pathological invasion into the ipsilateral scrotum. The initial diagnosis was made via ultrasonography and subsequently verified through surgical pathology. The rarity of the tumor\u2019s primary location, coupled with its extensive disease involvement, renders this case the first of its kind documented in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In future clinical practice, a broader spectrum of differential diagnoses should be considered for inguinal-scrotal masses in elderly male patients, including rare entities such as myxofibrosarcoma reported in this study. High-frequency superficial ultrasonography has demonstrated significant clinical value in the preliminary screening of such lesions. The integration of imaging characteristics, clinical presentation, and pathological findings can provide earlier and more accurate guidance for the diagnosis and management of myxofibrosarcoma.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1545507","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T05:27:14Z","timestamp":1751520434000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant myxofibrosarcoma in the inguinal region with invasion into the same-side scrotum: case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Yufei","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2016.05.008","article-title":"Myxofibrosarcoma","volume":"25","author":"Roland","year":"2016","journal-title":"Surg Oncol Clinics North America"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01458-1","article-title":"Multiple recurrent myxofibrosarcoma of the orbit: case report and review of the literature","volume":"20","author":"Du","year":"2020","journal-title":"BMC 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features of positive expression of Ki67 and P53 in breast cancer using radiomics","volume":"17","author":"Cui","year":"2021","journal-title":"Asia-Pacific J Clin Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04693-y","article-title":"Comparisons of magnetic resonance imaging, histopathological and Ki-67 labeling index findings in a single myxofibrosarcoma: a case report","volume":"18","author":"Tsujimura","year":"2024","journal-title":"J Med Case Rep"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000507334","article-title":"The biology of myxofibrosarcoma: state of the art and future perspectives","volume":"43","author":"Sambri","year":"2020","journal-title":"Oncol Res Treat"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-018-0935-9","article-title":"An entire clinical course of mediastinal myxofibrosarcoma treated by surgery and radiation","volume":"66","author":"Sugiura","year":"2018","journal-title":"Gen Thorac 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