{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:35:57Z","timestamp":1755218157021,"version":"3.43.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272015"],"award-info":[{"award-number":["82272015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"Objective<\/jats:title>To evaluate the value of micro-flow imaging (MFI) in monitoring ultrasound-guided microwave ablation (MWA) of papillary thyroid carcinoma (PTC) by comparing it with contrast-enhanced ultrasound (CEUS).<\/jats:p><\/jats:sec>Methods<\/jats:title>This study was conducted on 83 malignant nodules from 79 papillary thyroid carcinoma (PTC) patients treated between June 2022 and September 2023. These cases were divided into a control group (n=37) and an observation group (n=42) based on different guidance modalities during microwave ablation (MWA). The observation group underwent MFI monitoring, while the control group received CEUS monitoring. Clinical parameters were systematically compared between groups, including: 1) baseline clinical characteristics, 2) two-dimensional ultrasound features, 3) vascular patterns (MFI\/CEUS), 4) tumor volume (V), 5) volume reduction rate (VRR), 6) postoperative complications, and 7) patient satisfaction outcomes.<\/jats:p><\/jats:sec>Results<\/jats:title>All patients successfully underwent ablation. During multiple follow-ups post-MWA, no local recurrence or distant metastasis was observed in either group, and changes in V and VRR were similar (p &gt; 0.05). Consistency was also observed in the number of ablations, ablation time, and postoperative complications between the two groups (p &gt; 0.05). However, the MFI group had lower treatment costs and operation time compared to the CEUS group (p &lt; 0.05), and patients in the MFI group reported higher satisfaction with the procedure (p &lt; 0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The effectiveness and safety of MFI monitoring during PTC ablation are similar to those of CEUS, with the added advantages of lower costs and greater patient satisfaction, making MFI a preferable option for patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1545509","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T04:12:06Z","timestamp":1754453526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of micro-flow imaging and contrast-enhanced ultrasound in monitoring microwave ablation of papillary thyroid carcinoma: efficacy, safety, and 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