{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:37:37Z","timestamp":1793227057731,"version":"4.5.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    CIC-rearranged sarcoma (CRS) is a subgroup of small round blue cell tumors similar to Ewing\u2019s sarcoma but lacking the EWSR1 gene translocation. It is characterized by a CIC gene rearrangement on chromosome 19q13, with the most common partner gene being DUX4. In 2021, the WHO classification of central nervous system tumors (5th edition) introduced a new pathological classification for CRS based on bone and soft tissue tumor classifications, categorizing it as mesenchymal non-meningeal epithelial tumors. Primary CIC::DUX4 rearrangement sarcoma in the central nervous system is extremely rare, with no established standard treatment and a very poor prognosis. Herein, we present a case of intracranial CIC::DUX4 rearrangement diagnosed using DNA methylation classifiers and multiple omics diagnosis techniques. We also document the disease progression after chemoradiation therapy and subsequent\n                    <jats:italic>in situ<\/jats:italic>\n                    recurrence.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2025.1545700","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T05:40:34Z","timestamp":1769406034000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent CIC-rearranged sarcoma of central nervous system: a clinicopathological case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Shan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay Ka-Wai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Guan","sequence":"additional","affiliation":[{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ze","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-Shi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hui","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Sheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Keung","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders","place":["Shanghai, China"]},{"name":"Neurosurgical Institute, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Clinical Medical Center of Neurosurgery","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e28028","DOI":"10.1002\/pbc.28028","article-title":"Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors","volume":"67","author":"Lake","year":"2020","journal-title":"Pediatr Blood 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