{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:06Z","timestamp":1753892046656,"version":"3.41.2"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Fibromatosis is a rare neoplasm characterized by fibroblastic and myofibroblastic proliferation. Fibromatosis that occurred in the accessory breast has never been reported in the literature worldwide. We present a case of extra-abdominal fibromatosis of the accessory breast occurring in a 36-year-old Chinese female patient. The tumor was hard with unclear boundaries and adhered to surrounding tissues (6 \u00d7 4 \u00d7 3 cm). Despite that malignancy was initially suspected based on clinical, ultrasound, and magnetic resonance imaging (MRI) results, histopathology and immunohistochemistry showed an unexpected outcome. At the 2-year postoperative follow-up, there was no recurrence; the prognosis was explained to the patient. This case emphasizes the importance of clinical suspicion and histopathological evaluation and the need to raise awareness to promote early diagnosis and appropriate management of fibromatosis. We also present a literature review of varied presentations and treatment options for extra-abdominal fibromatosis.<\/jats:p>","DOI":"10.3389\/fonc.2025.1548521","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:32:09Z","timestamp":1750311129000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibromatosis of the accessory breast mimicking a malignant tumor: a rare case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0281","article-title":"Desmoid tumors: clinical features and treatment options for advanced disease","volume":"16","author":"Kasper","year":"2011","journal-title":"Oncologist"},{"volume-title":"WHO Classification of Tumours of Soft Tissue and Bone (IARC WHO Classification of Tumours)","year":"2013","author":"Fletcher","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020273","article-title":"Current treatment concepts for extra-abdominal desmoid-type fibromatosis: A narrative review","volume":"16","author":"Lee","year":"2024","journal-title":"Cancers (Basel)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071851","article-title":"Desmoid-type fibromatosis","volume":"12","author":"Garcia-Ortega","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.02.012","article-title":"Extra-abdominal desmoid fibromatosis: A review of management, current guidance and unanswered questions","volume":"42","author":"Eastley","year":"2016","journal-title":"Eur J Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.02.014","article-title":"Multicentric extra-abdominal desmoid tumours","volume":"57","author":"Wagstaff","year":"2004","journal-title":"Br J Plast Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds298","article-title":"The treatment of desmoid tumors: a stepwise clinical approach","author":"Bonvalot","year":"2012","journal-title":"Ann Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.11129","article-title":"Value of imaging findings in predicting post-operative recurrence of desmoid-type fibromatosis","volume":"19","author":"Wang","year":"2020","journal-title":"Oncol Lett"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/ajps.ajps_120_22","article-title":"Desmoid fibromatosis of the oesophagus creating an oesophageal diverticulum in a 2-year-old girl","volume":"21","author":"Murli","year":"2024","journal-title":"Afr J Paediatr Surg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320987641","article-title":"Oral losartan after limited mandibulectomy for treatment of desmoid-type fibromatosis","volume":"102","author":"Curry","year":"2023","journal-title":"Ear Nose Throat J"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.47176\/mjiri.36.94","article-title":"A submandibular fibromatosis; A case report and review of literature","volume":"36","author":"Mohammadi","year":"2022","journal-title":"Med J Islam Repub Iran"},{"key":"B12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3892\/mco.2023.2680","article-title":"Extra-abdominal recurrent aggressive fibromatosis: A case series and a literature review","volume":"19","author":"Asaad","year":"2023","journal-title":"Mol Clin Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.06.017","article-title":"Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: A nationwide prospective cohort from the French Sarcoma Group","author":"Penel","year":"2017","journal-title":"Eur J Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S165209","article-title":"A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature","volume":"11","author":"Duan","year":"2018","journal-title":"Onco Targets Ther"},{"key":"B15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00266-017-0948-2","article-title":"Desmoid tumor and silicone breast implant surgery: is there really a connection? A literature review","volume":"42","author":"Tzur","year":"2018","journal-title":"Aesth Plast Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0449","article-title":"\u03b2-Catenin mutation status and outcomes in sporadic desmoid tumors","volume":"18","author":"Mullen","year":"2013","journal-title":"Oncologist"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.115","article-title":"CTNNB1 mutation analysis is a useful tool for the diagnosis of desmoid tumors: a study of 260 desmoid tumors and 191 potential morphologic mimics","volume":"25","author":"Le Guellec","year":"2012","journal-title":"Mod Pathol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29564","article-title":"Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors","volume":"121","author":"Shang","year":"2015","journal-title":"Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211010619","article-title":"Contrast-enhanced ultrasound of breast fibromatosis: a case report","volume":"49","author":"Lin","year":"2021","journal-title":"J Int Med Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.8.1519","article-title":"Sonographic appearances of desmoid tumors","volume":"33","author":"Lou","year":"2014","journal-title":"J Ultrasound Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-230670","article-title":"Largest size of extra-abdominal fibromatosis of axilla in a young man","volume":"12","author":"Kumar","year":"2019","journal-title":"BMJ Case Rep"},{"key":"B22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5334\/jbsr.1612","article-title":"Desmoid-type fibromatosis of the breast mimicking carcinoma","volume":"103","author":"Wuyts","year":"2019","journal-title":"J Belg Soc Radiol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.13104\/imri.2017.21.3.162","article-title":"The imaging features of desmoid tumors: the usefulness of difusion weighted imaging to diferentiate between desmoid and Malignant soft tissue tumors","volume":"21","author":"Lee","year":"2017","journal-title":"Investig Magn Reson Imaging"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-009-0458-7","article-title":"Imaging of superficial and deep fibromatosis","volume":"114","author":"Guglielmi","year":"2009","journal-title":"Radiol Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-02294-x","article-title":"Isolated infratemporal fossa desmoid fibromatosis: A rare case report and review of literature","volume":"74","author":"Munnangi","year":"2022","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2020.05.004","article-title":"Resection of a desmoid-type fibromatosis with a CTNNB1 p.S45P mutation using a cervico-thoracic approach: A case report and literature review","volume":"48","author":"Sato","year":"2021","journal-title":"Auris Nasus Larynx"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/anr3.12129","article-title":"Paraspinal desmoid fibromatosis after lumbar epidural analgesia","volume":"9","author":"Remedios","year":"2021","journal-title":"Anaesth Rep"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_698_20","article-title":"Desmoplastic fibroma of the Mandible with unusual histopathological features","volume":"64","author":"Nisha","year":"2021","journal-title":"Indian J Pathol Microbiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.11.005","article-title":"Management of sporadic desmoid-type fibromatosis: a European consensus approach based on patients\u2019 and professionals\u2019 expertise-a sarcoma patients EuroNet and European Organisation for Research and Treatment of Cancer\/Soft Tissue and Bone Sarcoma Group initiative","volume":"51","author":"Kasper","year":"2015","journal-title":"Eur J Cancer"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.02.008","article-title":"Management of desmoid tumours: A nationwide survey of labelled reference centre networks in France","volume":"58","author":"Penel","year":"2016","journal-title":"Eur J Cancer"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001517","article-title":"Lower rate of CTNNB1 mutations and higher rate of APC mutations in desmoid fibromatosis of the breast: A series of 134 tumors","volume":"44","author":"Norkowski","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007-8096.2024.04.010","article-title":"Breast fibromatosis:a clinicopathologic analysis of fourteen cases and review of literature","volume":"31","author":"Tu","year":"2024","journal-title":"J Diag Pathol April"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109406","article-title":"Long-term diagnostic value of MRI in detecting recurrent aggressive fibromatosis at two multidisciplinary sarcoma centers","volume":"134","author":"Sedaghat","year":"2021","journal-title":"Eur J Radiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1517::AID-CNCR3>3.0.CO;2-9","article-title":"Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: A comparative review of 22 articles","volume":"88","author":"Nuyttens","year":"2000","journal-title":"Cancer"},{"key":"B35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000507842","article-title":"Desmoid type fibromatosis of the breast: ten-year institutional results of imaging, histopathology, and surgery","volume":"16","author":"Lorenzen","year":"2021","journal-title":"Breast Care (Basel)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12957-015-0450-8","article-title":"Postoperative recurrence of desmoid tumors: clinical and pathological perspectives","volume":"13","author":"Wang","year":"2015","journal-title":"World J Surg Oncol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2024-264208","article-title":"Desmoid fibromatosis of the breast","volume":"18","author":"Amjad","year":"2025","journal-title":"BMJ Case Rep"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1482024","article-title":"Desmoid-type fibromatosis of the breast: a case report and literature review","volume":"15","author":"Zhao","year":"2025","journal-title":"Front Oncol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1438050","article-title":"Desmoid-type fibromatosis of the breast in a male patient following cosmetic surgery: a rare case report","volume":"14","author":"Correa Sandoval","year":"2024","journal-title":"Front Oncol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2023.09.104","article-title":"Desmoid fibromatosis in a male breast with gynecomastia: A case report","volume":"19","author":"Moussaddykine","year":"2023","journal-title":"Radiol Case Rep"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2022.41.184.28549","article-title":"Fibromatose desmo\u00efde mammaire: \u00e0 propos de deux cas et revue de la literature [Desmoid-type fibromatosis of the breast: about two cases and literature review","volume":"41","author":"Laakom","year":"2022","journal-title":"Pan Afr Med J"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-020-01145-5","article-title":"Fibromatosis of the breast: a 10-year multi-institutional experience and review of the literature","volume":"28","author":"Boland","year":"2021","journal-title":"Breast Cancer"},{"key":"B43","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1093\/jbi\/wbab051","article-title":"Breast fibromatosis: radiologic-pathologic correlation","volume":"3","author":"Winkler","year":"2021","journal-title":"J Breast Imag"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.14008","article-title":"Breast fibromatosis: Imaging and clinical findings","volume":"26","author":"Liu","year":"2020","journal-title":"Breast J"},{"key":"B45","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/tbj.13506","article-title":"Breast fibromatosis: Making the case for primary vs secondary subtypes","volume":"26","author":"Ghanta","year":"2020","journal-title":"Breast J"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjy249","article-title":"Silicone breast implant associated fibromatosis","volume":"2018","author":"Hill","year":"2018","journal-title":"J Surg Case Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.radcr.2017.09.011","article-title":"Fibromatosis of the breast mimicking cancer: A case report","volume":"13","author":"Grimaldi","year":"2017","journal-title":"Radiol Case Rep"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-017-1148-x","article-title":"Medical treatment of mammary desmoid-type fibromatosis: which benefit","volume":"15","author":"Scheer","year":"2017","journal-title":"World J Surg Oncol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx065","article-title":"Fibromatosis of the breast: diagnostic accuracy of core needle biopsy","volume":"148","author":"Kuba","year":"2017","journal-title":"Am J Clin Pathol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1548521\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:32:11Z","timestamp":1750311131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1548521\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":49,"alternative-id":["10.3389\/fonc.2025.1548521"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1548521","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"article-number":"1548521"}}