{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:45:31Z","timestamp":1786794331493,"version":"build-2736575974"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Male choriocarcinoma is an extremely rare malignant tumor. It has the characteristics of hidden onset, easy invasion and metastasis. Clinically, when choriocarcinoma is found in a patient, most of the tumor cells have metastasized to distant organs. This case reports a 65-year-old man with choriocarcinoma with two intracerebral hemorrhages as the main symptom. In this case, we consider the origin of intracranial choriocarcinoma to be testicular. We analyzed the clinical data of this patient and summarized the cases of male choriocarcinoma reported in the past, so as to arouse the attention of clinicians.<\/jats:p>","DOI":"10.3389\/fonc.2025.1549261","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:10:26Z","timestamp":1744258226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Male choriocarcinoma presenting with intracerebral hemorrhage: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1752-1947-5-501","article-title":"Primary choriocarcinoma of the renal pelvis presenting as intracerebral hemorrhage: a case report and review of the literature","volume":"5","author":"Kyriakou","year":"2011","journal-title":"J Med Case Rep"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb01423.x","article-title":"Choriocarcinoma presenting as a cutaneous metastasis","volume":"22","author":"Chhieng","year":"1995","journal-title":"J Cutan Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4463","article-title":"Choriocarcinoma of unknown origin with multiple organ metastasis and cerebral hemorrhage: A case report and literature review","volume":"11","author":"Wei","year":"2016","journal-title":"Oncol Lett"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.36655","article-title":"Medical literature writing with ChatGPT: A rare case of choriocarcinoma syndrome with hemorrhagic brain metastases due to burned out metastatic mixed testicular cancer","volume":"15","author":"Le","year":"2023","journal-title":"Cureus"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.01.053","article-title":"Pure testicular choriocarcinoma Cannonball metastases as a presenting imaging feature: A case report and a review of literature","volume":"16","author":"Aftan","year":"2021","journal-title":"Radiol Case Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.07.023","article-title":"Pitfalls in diagnosis and management of testicular choriocarcinoma metastatic to the brain: report of 2 cases and review of literature","volume":"106","author":"Hoffman","year":"2017","journal-title":"World Neurosurg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucir.2014.08.001","article-title":"Histology of a cerebral hemorrhage: AVM as a seat of a metastatic choriocarcinoma","volume":"26","author":"Moroll\u00f3n","year":"2015","journal-title":"Neurocirugia (Astur)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011362.rep","article-title":"Hemorrhagic collision metastasis in a cerebral arteriovenous malformation","volume":"7","author":"Sundarakumar","year":"2015","journal-title":"J neurointerv Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1136\/bcr-2015-212777","article-title":"Metastatic choriocarcinoma induced separate simultaneous intracerebral haemorrhages: a very rare occurrence and its novel association with Klinefelter syndrome","volume":"12","author":"Joret","year":"2015","journal-title":"BMJ Case Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.220012","article-title":"Neurological picture. 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