{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:15Z","timestamp":1787026995953,"version":"build-2736575974"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare and predict the disease burden of larynx cancer in China and the United States (US) using data from the Global Burden of Disease Study 2021 (GBD2021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the data from GBD2021 to systematically analyze and compare the incidence and mortality of laryngeal cancer in China and the United States, and used the Autoregressive Integrated Moving Average (ARIMA) model to predict the trends in the next 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, China had 38,904.86 (95% UI: 30,369.67\u201349,486.18) larynx cancer cases and 19,799.45 (95% UI: 15,579.57\u201325,023.24) deaths, reflecting a 2.52-fold and 53.8% increase from 1990. In the US, there were 16,371.45 (95% UI: 15,509.40\u201317,060.58) cases and 4,620.32 (95% UI: 4,339.97\u20134,835.98) deaths, showing a 33.3% and 10.04% increase from 1990. Projections indicate a decline in age-standardized incidence and mortality rates in China, while the US is expected to see a slight decline in incidence but continued significant reductions in mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>China has a significantly higher number of larynx cancer cases compared to the US, with a higher incidence rate. However, mortality rates are relatively similar. Larynx cancer will remain a notable disease burden in both countries over the next decade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1552514","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:48:47Z","timestamp":1750211327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Trends and prediction of incidence and mortality burden of larynx cancer in China and the US: a systematic analysis of the Global Burden of Disease Study 2021"],"prefix":"10.3389","volume":"15","author":[{"given":"Weimin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and neck cancer","volume":"382","author":"Chow","year":"2020","journal-title":"New Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3322\/caac.21386","article-title":"An update on larynx cancer","volume":"67","author":"Steuer","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e13689","DOI":"10.1111\/ecc.13689","article-title":"The global, regional, national burden of laryngeal cancer and its attributable risk factors (1990-2019) and predictions to 2035","volume":"31","author":"Lin","year":"2022","journal-title":"Eur J Cancer Care (Engl)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.01.02","article-title":"Incidence and mortality of laryngeal cancer in China, 2015","volume":"32","author":"He","year":"2020","journal-title":"Chin J Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102762","article-title":"Global burden of larynx cancer, 1990-2017: estimates from the global burden of disease 2017 study","volume":"12","author":"Deng","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.v12.15","article-title":"Trend and projection of larynx cancer incidence and mortality in China from 1990 to 2044: A Bayesian age-period-cohort modeling study","volume":"12","author":"Ye","year":"2023","journal-title":"Cancer Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4390-x","article-title":"Characteristics of cigarette smoking without alcohol consumption and laryngeal cancer: overall and time-risk relation. 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