{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:30:27Z","timestamp":1774279827645,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Contrast-enhanced mammography (CEM) is an emerging imaging technique. This study aims to compare the diagnostic accuracy of CEM and magnetic resonance imaging (MRI) for breast lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on patients who underwent both CEM and MRI at our institution from July 2019 to April 2024. All imaging reports were prepared in accordance with the Breast Imaging Reporting and Data System (BI-RADS) guidelines established by the American College of Radiology (ACR). The final diagnosis was established using pathology as the \u201cgold standard.\u201d The diagnostic performance of the two methods in detecting breast lesions was compared using sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 292 patients underwent paired CEM and MRI examinations, with an average age of 46.9 years. Among the 301 breast lesions identified, 121 (40.2%) were benign, and 180 (59.8%) were malignant. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CEM for diagnosing benign and malignant breast lesions were 98.9%, 78.5%, 90.7%, 87.3%, and 97.9%, respectively. The corresponding values for MRI were 98.9%, 72.7%, 88.4%, 84.4%, and 97.8%. No significant difference was observed in the diagnostic performance between the two methods (p &amp;gt; 0.05). The areas under the curve (AUC) for CEM and MRI were 0.887 (95% CI: 0.85\u20130.92) and 0.858 (95% CI: 0.81\u20130.90), respectively (p = 0.400).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As an emerging imaging technique for detecting and diagnosing breast lesions, CEM demonstrates diagnostic performance comparable to that of MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1557800","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:36:12Z","timestamp":1767854172000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of diagnostic performance between contrast-enhanced mammography and breast magnetic resonance imaging"],"prefix":"10.3389","volume":"15","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: A Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000001474","article-title":"Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020","volume":"134","author":"Cao","year":"2021","journal-title":"Chin Med J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4636-4","article-title":"Digital mammography screening: sensitivity of the programme dependent on breast density","volume":"27","author":"Weigel","year":"2016","journal-title":"Eur Radiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-3-200302040-00008","article-title":"Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography","volume":"138","author":"Carney","year":"2003","journal-title":"Ann Intern Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.radi.2022.01.006","article-title":"Comparison of the diagnostic performance of Magnetic Resonance Imaging (MRI), ultrasound and mammography for detection of breast cancer based on tumor type, breast density and patient\u2019s history: A review","volume":"28","author":"Aristokli","year":"2022","journal-title":"Radiography"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-020-00497-w","article-title":"Comparison of BSGI, MRI, mammography, and ultrasound for the diagnosis of breast lesions and their correlations with specific molecular subtypes in Chinese women","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Med Imaging"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.12.9186","article-title":"Malignant invasion of the nipple-areolar complex of the breast: usefulness of breast MRI","volume":"201","author":"Moon","year":"2013","journal-title":"Am J Roentgenol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/07357907.2016.1251943","article-title":"Magnetic resonance imaging in the pre-surgical staging of breast cancer: our experience","volume":"35","author":"Rabasco","year":"2016","journal-title":"Cancer Invest"},{"key":"B9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1148\/radiol.2021201948","article-title":"Contrast-enhanced mammography: state of the art","volume":"299","author":"Jochelson","year":"2021","journal-title":"Radiology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ejrad.2008.07.035","article-title":"Contrast-enhanced digital mammography","volume":"69","author":"Dromain","year":"2009","journal-title":"Eur J Radiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2020.09.003","article-title":"Contrast-enhanced mammography: past, present, and future","volume":"69","author":"Sogani","year":"2021","journal-title":"Clin Imaging"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12627","article-title":"Added value of contrast-enhanced spectral mammography in postscreening assessment","volume":"22","author":"Tardivel","year":"2016","journal-title":"Breast J"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4336-0","article-title":"Contrast-enhanced spectral mammography in recalls from the Dutch breast cancer screening program: validation of results in a large multireader, multicase study","volume":"26","author":"Lalji","year":"2016","journal-title":"Eur Radiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1944-y","article-title":"Dual-energy contrast-enhanced digital mammography: initial clinical results","volume":"21","author":"Dromain","year":"2010","journal-title":"Eur Radiol"},{"key":"B15","article-title":"Breast Imaging Reporting and Data System","author":"Magny","year":""},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019182947","article-title":"Breast MRI: state of the art","volume":"292","author":"Mann","year":"2019","journal-title":"Radiology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019190079","article-title":"Contrast-enhanced mammography: current applications and future directions","volume":"39","author":"Ghaderi","year":"2019","journal-title":"RadioGraphics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3154-5","article-title":"Contrast-enhanced spectral mammography in patients referred from the breast cancer screening programme","volume":"24","author":"Lobbes","year":"2014","journal-title":"Eur Radiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211412","article-title":"Contrast-enhanced mammography: A systematic review and meta-analysis of diagnostic performance","volume":"302","author":"Cozzi","year":"2022","journal-title":"Radiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1148\/radiol.2017161592","article-title":"Newly diagnosed breast cancer: comparison of contrast-enhanced spectral mammography and breast MR imaging in the evaluation of extent of disease","volume":"285","author":"Lee-Felker","year":"2017","journal-title":"Radiology"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12121084","article-title":"Bilateral contrast-enhanced dual-energy digital mammography: feasibility and comparison with conventional digital mammography and MR imaging in women with known breast carcinoma","volume":"266","author":"Jochelson","year":"2013","journal-title":"Radiology"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2385-0","article-title":"Preclinical study of diagnostic performances of contrast-enhanced spectral mammography versus MRI for breast diseases in China","volume":"5","author":"Wang","year":"2016","journal-title":"SpringerPlus"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.12659\/msm.893018","article-title":"Comparison between breast MRI and contrast-enhanced spectral mammography","volume":"21","author":"Jakubowicz","year":"2015","journal-title":"Med Sci Monitor"},{"key":"B24","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1148\/radiol.212530","article-title":"Contrast-enhanced mammography versus contrast-enhanced breast MRI: A systematic review and meta-analysis","volume":"305","author":"P\u00f6tsch","year":"2022","journal-title":"Radiology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.7150\/jca.79747","article-title":"Comparing the diagnostic performance of contrast-enhanced mammography and breast MRI: a systematic review and meta-analysis","volume":"14","author":"Neeter","year":"2023","journal-title":"J Cancer"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081890","article-title":"Contrast-enhanced mammography versus breast magnetic resonance imaging: A systematic review and meta-analysis","volume":"12","author":"Gelardi","year":"2022","journal-title":"Diagnostics"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190887","article-title":"Diagnostic performance of MRI, molecular breast imaging, and contrast-enhanced mammography in women with newly diagnosed breast cancer","volume":"293","author":"Sumkin","year":"2019","journal-title":"Radiology"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162740","article-title":"Dual-energy contrast-enhanced spectral mammography: enhancement analysis on BI-RADS 4 non-mass microcalcifications in screened women","volume":"11","author":"Chu","year":"2016","journal-title":"PloS One"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1177\/0284185118822639","article-title":"Contrast-enhanced spectral mammography in the evaluation of breast suspicious calcifications: diagnostic accuracy and impact on surgical management","volume":"60","author":"Houben","year":"2019","journal-title":"Acta Radiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180245","article-title":"Added value of contrast-enhanced mammography in assessment of breast asymmetries","volume":"92","author":"Wessam","year":"2019","journal-title":"Br J Radiol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2022.21562","article-title":"Contrast-enhanced spectral mammography:are kinetic patterns useful for differential diagnosis of enhanced lesions","volume":"29","author":"Rong","year":"2023","journal-title":"Diagn Interventional Radiol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.07.004","article-title":"Contrast-enhanced spectral mammography as work-up tool in patients recalled from breast cancer screening has low risks and might hold clinical benefits","volume":"94","author":"Houben","year":"2017","journal-title":"Eur\u00a0J Radiol"}],"updated-by":[{"DOI":"10.3389\/fonc.2026.1829116","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000}}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1557800\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:43:11Z","timestamp":1774276991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1557800\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":32,"alternative-id":["10.3389\/fonc.2025.1557800"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1557800","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"article-number":"1557800"}}