{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:31:04Z","timestamp":1784593864226,"version":"3.55.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Myeloid Leukemias (ML) are neoplastic disorders characterized by the abnormal production of myeloid blood cells and disrupted hematopoiesis. Limited research exists on regional and demographic trends in ML mortality. This study investigates ML mortality patterns in the U.S. from 1999 to 2022, focusing on geographic and demographic disparities using age-adjusted mortality rates (AAMR) and average annual percent change (AAPC). Data were obtained from the CDC WONDER database, with AAMRs calculated per 100,000 people and stratified by region, state, urbanicity, sex, and race. AAPCs were computed using the National Cancer Institute\u2019s (NCI) Joinpoint Regression Program (Joinpoint V 4.9.0.0, NCI). Between 1999 and 2022, there were 299,221 ML-related deaths nationwide. While most U.S. regions showed a non-significant downward trend in mortality, the Midwest demonstrated a non-significant upward trend and consistently higher AAMRs. States with the highest AAMRs included Iowa, Kansas, Minnesota, and the Dakotas\u2014predominantly rural states. Rural areas overall had higher AAMRs than urban areas. Males and White individuals had the highest mortality across all regions, with the Midwest showing the highest AAMRs for both sexes. Although ML mortality declined significantly from 1999 to 2007, it showed a non-significant increase from 2007 to 2022, despite therapeutic advancements. Persistent disparities\u2014particularly among rural Midwestern populations, White patients, and males\u2014highlight the need for targeted interventions and further research to address these geographic and demographic inequities.<\/jats:p>","DOI":"10.3389\/fonc.2025.1560797","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T04:11:23Z","timestamp":1752207083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional, demographic, and temporal trends in myeloid leukemia mortality in the United States (1999-2022): a comprehensive analysis using CDC WONDER"],"prefix":"10.3389","volume":"15","author":[{"given":"Jenna","family":"Lehn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Billion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2006.06.003","article-title":"Principles of dendritic cell-based immunotherapy in myeloid leukemia","volume":"211","author":"Westers","year":"2006","journal-title":"Immunobiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33458","article-title":"De novo acute myeloid leukemia: A population-based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) database, 1980 to 2017","volume":"127","author":"Sasaki","year":"2021","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24767","article-title":"Early mortality and overall survival of acute myeloid leukemia based on facility type","volume":"92","author":"Bhatt","year":"2017","journal-title":"Am J Hematol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1182\/blood-2022-171171","article-title":"Racial disparities in mortality trends from acute myeloid leukemia: A population-based study in the United States between 2000 and 2019","volume":"140","author":"Al Armashi","year":"2022","journal-title":"Blood"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2025.03.006","article-title":"Analyzing two decades of leukemia mortality in the U.S. (1999-2020)","author":"Aziz","year":"2025","journal-title":"Clin Lymphoma Myeloma Leukemia"},{"key":"B7","unstructured":"CDC wonder\n          \n          Centers for Disease Control and Prevention\n          Centers for Disease Control and Prevention"},{"key":"B8","unstructured":"2013 NCHS urban\u2013rural classification scheme for counties"},{"key":"B9","unstructured":"Multiple cause of death, 1999\u20132020 request\n          \n          Centers for Disease Control and Prevention\n          Centers for Disease Control and Prevention"},{"key":"B10","unstructured":"Age standardization of death rates; 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