{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:00:35Z","timestamp":1771920035058,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Intraductal papillary mucinous neoplasm (IPMN) with invasive carcinoma is a rare type of pancreatic cancer that has a better prognosis than classic pancreatic infiltrating ductal carcinoma. Most distant metastases occur in the lymph nodes, lungs, liver, and bones at advanced stages. We report a rare case of an IPMN with invasive carcinoma that metastasized to the uterus, resulting in long-term survival after debulking surgery combined with hyperthermic intraperitoneal chemotherapy on a systemic treatment basis. This rare case highlights the need for oncologists and gynecologists to be vigilant regarding these uncommon metastatic diseases and exercise caution in diagnosis. Comprehensive treatments, including debulking surgery, may improve survival.<\/jats:p>","DOI":"10.3389\/fonc.2025.1562588","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:18:38Z","timestamp":1771910318000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic intraductal papillary mucinous neoplasm with invasive carcinoma and uterine metastasis: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Yingxue","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Oncology, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanghua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Affiliated Hospital Of QingDao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengli Oilfield Central Hospital","place":["Dongying, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005535","article-title":"Incidental pancreatic cystic neoplasms in an asymptomatic healthy population of 21,745 individuals:large-scale,single-center cohort study","volume":"95","author":"Chang","year":"2016","journal-title":"Med (Baltimore)"},{"key":"B2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.47892\/rgp.2020.401.1030","article-title":"Perfil cl\u00ednico y resultados de la pancreatitis aguda en la Unidad de Cuidados Intensivos e Intermedios de un hospital general [Clinical profile and results of acute pancreatitis in the Intensive and Intermediate Care Unit of a general hospital","volume":"40","author":"Arroyo-S\u00e1 Nchez","year":"2020","journal-title":"Rev Gastroenterol Peru"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.07.007","article-title":"Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas","volume":"17","author":"Tanaka","year":"2017","journal-title":"Pancreatology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002015","article-title":"Development and validation of a multi-institutional preoperative nomogram for predicting grade of dysplasia in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas: A report from the pancreatic surgery consortium","volume":"267","author":"Attiyeh","year":"2018","journal-title":"Ann Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.3349","article-title":"Assessment of a revised management strategy for patients with intraductal papillary mucinous neoplasms involving the main pancreatic duct","volume":"152","author":"Sugimoto","year":"2017","journal-title":"JAMA Surg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001008","article-title":"Patterns of recurrence after resection of IPMN: who, when, and how","volume":"262","author":"Marchegiani","year":"2015","journal-title":"Ann Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.5.717","article-title":"Prognosis of Malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma","volume":"51","author":"Maire","year":"2002","journal-title":"Gut"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/1457496918766727","article-title":"Intraductal papillary mucinous neoplasms of the pancreas: A nationwide registry-based study","volume":"107","author":"Aronsson","year":"2018","journal-title":"Scand J Surg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01747.x","article-title":"Adenocarcinoma metastatic to the uterine cervix: a case series","volume":"38","author":"P\u00e9rez-Montiel","year":"2012","journal-title":"J Obstet Gynaecol Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2163::aid-cncr2820501032>3.0.co;2-f","article-title":"Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases","volume":"50","author":"Kumar","year":"1982","journal-title":"Cancer"},{"key":"B11","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/0090-8258(80)90041-4","article-title":"Carcinoma metastatic in the cervix","volume":"9","author":"Way","year":"1980","journal-title":"Gynecol Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840501)53:9<1978::aid-cncr2820530929>3.0.co;2-1","article-title":"Metastases to the female genital tract","volume":"53","author":"Mazur","year":"1984","journal-title":"Anal 325 cases. Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2651-5","article-title":"Endometrial metastases in breast cancer: a rare event","volume":"287","author":"Aksahin","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"bcr0920092229","DOI":"10.1136\/bcr.09.2009.2229","article-title":"Endometrial metastasis of colorectal cancer with coincident endometrial adenocarcinoma","volume":"2010","author":"Colling","year":"2010","journal-title":"BMJ Case Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"bcr2018224435","DOI":"10.1136\/bcr-2018-224435","article-title":"Endometrial metastasis of primary Malignant melanoma of the brain","volume":"2018","author":"Little","year":"2018","journal-title":"BMJ Case Rep"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009-3419.2025.102.27","article-title":"A Case of Endometrial Metastasis in Lung Adenocarcinoma after EGFR-TKIs Treatment Failure and Literature Review","volume":"28","author":"Shen","year":"2025","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(16)36251-2","article-title":"Extrapelvic carcinoma metastatic to the uterus","volume":"82","author":"Stemmermann","year":"1961","journal-title":"Am J Obstet Gynecol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12195","article-title":"Metastases of basal-like breast invasive ductal carcinoma to the endometrium: A case report and review of the literature","volume":"6","author":"Huo","year":"2015","journal-title":"Thorac Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2020.01.008","article-title":"Metastatic invasive lobular carcinoma of the breast to the endometrium presenting with abnormal uterine bleeding; Case report","volume":"51","author":"Arif","year":"2020","journal-title":"Ann Med Surg (Lond)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"13030\/qt9m97010n","DOI":"10.5070\/D3274053161","article-title":"Metastatic Malignant melanoma in an endometrial polyp","volume":"27","author":"Ulmer","year":"2021","journal-title":"Dermatol Online J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/s0301-2115(98)00268-1","article-title":"Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy","volume":"83","author":"Piura","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.907638","article-title":"Endometrial metastasis from ductal breast carcinoma: A case report with literature review","volume":"19","author":"Rahmani","year":"2018","journal-title":"Am J Case Rep"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14056","article-title":"Response to lorlatinib on a patient with ALK-rearranged non-small cell lung cancer harboring 1151Tins mutation with uterine metastasis","volume":"12","author":"Kobayashi","year":"2021","journal-title":"Thorac Cancer"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01807.x","article-title":"Signet-ring cell carcinoma of the breast with uterine metastasis treated with extensive cytoreductive surgery: a case report and brief review of the literature","volume":"38","author":"Ertas","year":"2012","journal-title":"J Obstet Gynaecol Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618","article-title":"Hyperthermic intraperitoneal chemotherapy in ovarian cancer","volume":"378","author":"van Driel","year":"2018","journal-title":"N Engl J Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70210-3","article-title":"Cytoreductive surgery plus hyperthermic perioperative chemotherapy to treat peritoneal metastases from colorectal cancer: standard of care or an experimental approach","volume":"13","author":"Sugarbaker","year":"2012","journal-title":"Lancet Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1562588\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:18:42Z","timestamp":1771910322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1562588\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":26,"alternative-id":["10.3389\/fonc.2025.1562588"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1562588","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"article-number":"1562588"}}