{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:43:27Z","timestamp":1763729007055,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatic lymphoma is a rare pancreatic malignancy that is challenging to differentiate from diseases such as pancreatic cancer (PC). Although pathological examination of specimens obtained through surgery or endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) can aid in diagnosis, factors such as the occasional need for surgery and the variability in specimen quality from EUS-FNA complicate the diagnostic process. Misdiagnosis of pancreatic lymphoma as PC often leads to unnecessary surgery. In addition, surgical intervention may be necessary as a second-line treatment option for pancreatic lymphoma patients presenting with severe gastrointestinal symptoms. However, an optimal postoperative treatment strategy remains undefined, particularly in cases with extensive invasion, thereby impacting long-term survival. This lack of consensus underscores the need for further research to establish evidence-based therapeutic protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Description<\/jats:title><jats:p>We present the case of a 55-year-old patient (abdominal pain for over one month, intensified for two weeks). Imaging studies suggested a hypodense mass in the tail of the pancreas with ill-defined margins extending to the spleen, as well as a hypodense lesion within the spleen. The patient underwent surgical intervention, and postoperative pathological analysis confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL). Following surgery, the patient was initially treated with a short-term C2PET oral chemotherapy regimen, which was subsequently transitioned to the R-CHOP regimen. This therapeutic approach resulted in a favorable outcome, with the patient achieving a 5-year survival period. As far as we know, this may be the first reported case of pancreatic lymphoma with such a widespread involvement, in which patient underwent surgery and postoperative chemotherapy and obtained a 5-year survival period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Literature Review<\/jats:title><jats:p>We reviewed previously reported cases of the DLBCL pancreatic lymphoma located in the body and tail of pancreas, and conducted a comparative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purposes and Clinical Relevance<\/jats:title><jats:p>Our objectives are twofold: first, to highlight the critical role of preoperative EUS-FNA and positron emission tomography\u2013computed tomography in the diagnostic evaluation for patients with pancreatic mass and suspected lesions in immune-associated organs; and second, to propose evidence-based recommendations for postoperative chemotherapy in cases of DLBCL involving the pancreas.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1563729","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:10:46Z","timestamp":1745899846000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report of rare pancreatic lymphoma: wide range of diffuse large B-cell lymphoma located in the body and tail of pancreas"],"prefix":"10.3389","volume":"15","author":[{"given":"Xiang","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i24.4467","article-title":"Pancreatic T\/histiocyte-rich large B-cell lymphoma: A case report and review of literature","volume":"23","author":"Zheng","year":"2017","journal-title":"World J gastroenterol"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1097\/00006676-199409000-00019","article-title":"Pancreatic lymphoma: is it a surgical disease","volume":"9","author":"Behrns","year":"1994","journal-title":"Pancreas"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008282818705","article-title":"Primary extranodal non-Hodgkin\u2019s lymphomas. 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