{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:00:51Z","timestamp":1790787651560,"version":"4.1.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560345"],"award-info":[{"award-number":["81560345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Central venous access for cancer chemotherapy is crucial for patients undergoing long-term treatment. The internal jugular vein (IJV) and subclavian vein (SCV) are commonly used for implantable port insertion, though the optimal choice remains debated. This meta-analysis aims to compare the safety and effectiveness of IJV and SCV for central venous implantable port insertion in cancer chemotherapy patients based on randomized controlled trials (RCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically reviewed RCTs comparing IJV and SCV for implantable port insertion. The primary endpoint was complication, while secondary endpoints included procedure failure rate, procedure duration, patient satisfaction, and pain perception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7 studies based on 6 RCTs met the inclusion criteria. The baseline characteristics (age, sex, port side, and duration of implant) of patients in both groups were comparable. According to patient-reported outcomes, the SCV group experienced higher rates of total complications (risk ratio [RR]: 0.52 [0.29, 0.93], P = 0.03, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 71%), catheter misplacement (RR: 0.51 [0.27, 0.96], P = 0.04, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 35%), and port\/catheter-related bloodstream infections (RR: 0.37 [0.17, 0.81], P = 0.01, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%). Similarly, according to catheter days, the SCV group achieved higher rates of total complications (RR: 0.48 [0.35, 0.67], P &amp;lt; 0.0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 29%) and port\/catheter-related bloodstream infections (PRBIs) (RR: 0.32 [0.14, 0.72], P = 0.006, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%). Pain perception (mean difference [MD]: -1.60 [-1.93, -1.27], P &amp;lt; 0.00001) was also worse in the SCV group. However, the duration of the procedure (MD: 11.55 [0.57, 22.54] minutes, P = 0.04, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 97%) was longer in the IJV group. The procedural failure rate was comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For cancer chemotherapy patients, the IJV appears to be a safer and less painful alternative to the SCV for central venous port insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:uri>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:uri>, identifier CRD42025641904.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1566757","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T06:10:51Z","timestamp":1748239851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparing internal jugular vein and subclavian vein for central venous insertion of implantable ports in cancer chemotherapy: a meta-analysis of 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