{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:21:24Z","timestamp":1776846084828,"version":"3.51.2"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lymphoma is a significant cause of mortality among people living with human immunodeficiency virus (PLWH). The objective of our study was to assess the characteristics of lymphomas in PLWH in a single center from the southeast of Romania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the prevalence and clinical and demographic characteristics of patients with lymphoma associated with HIV\/AIDS monitored over a period of 15 years. Kaplan\u2013Meier analysis was used to estimate survival rates and evaluate the risk of mortality in lymphoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 476 new cases of HIV\/AIDS registered, 9 cases of lymphoma were identified, representing a prevalence of 1.89%. Overall mortality was 13.6%, with lymphoma contributing to 10.76% of HIV\/AIDS-related deaths. The average age at lymphoma diagnosis was 37 years, with most patients being men and smokers with sexually transmitted HIV. Common coinfections included hepatitis B virus (HBV) and tuberculosis. Advanced-stage disease (Ann Arbor stage IV) and type B clinical symptoms were present in half of the cases. Oncological treatment was provided in 5 cases, achieving a survival rate of 30%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The high mortality highlights the need for early diagnosis and an integrated therapeutic approach to improve the prognosis of patients with HIV-associated lymphomas.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1569433","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:47:41Z","timestamp":1750225661000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective analysis of HIV-associated lymphomas: insights from a single Romanian center over 15 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