{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:40Z","timestamp":1787837200404,"version":"build-2784847793"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Primary leiomyosarcoma of the breast is an extremely rare tumor originating from the mesenchymal tissue of the breast. The clinical data of a case of primary leiomyosarcoma of the breast admitted to our hospital on September 11, 2024 were analyzed. A 58-year-old woman had a right breast mass for a week. Physical examination revealed an irregular mass at approximately 2\u20133 points in the right upper quadrant of the breast. Laboratory tests showed normal results for the tumor marker CA153. Color Doppler ultrasound considered solid nodules (BI-RADS Class 4b). Modified radical mastectomy and tertiary axillary lymph node dissection was performed on 2024-9-13, and the patient underwent adjuvant chemotherapy after surgery and recovered well. Pathological findings were reported one week after surgery: breast leiomyosarcoma. This article presents the diagnosis and treatment of primary leiomyosarcoma of breast through a clinical case, which provides a reference for clinicians. This case highlights the importance of pathological examination in the diagnosis of rare tumors, and suggests the need to combine imaging, laboratory examination and pathological findings to make a comprehensive judgment of breast masses.<\/jats:p>","DOI":"10.3389\/fonc.2025.1571029","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:25:43Z","timestamp":1747891543000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Primary leiomyosarcoma of the breast"],"prefix":"10.3389","volume":"15","author":[{"given":"Haoqiang","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103474","article-title":"Outcome improvement with chemotherapy and radiotherapy in primary, localized, radiation-associated angiosarcoma of the breast region: a retrospective case series analysis","volume":"9","author":"Palassini","year":"2024","journal-title":"Esmo Open"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2024.476","article-title":"Primary leiomyosarcoma with osteosarcomatous differentiation of the breast","volume":"14","author":"Sethi","year":"2024","journal-title":"Autops Case Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.939437","article-title":"Primary leiomyosarcoma of the breast: a successful surgical treatment in a 45-year-old woman","volume":"24","author":"Samenova","year":"2023","journal-title":"Am J Case Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e236013","DOI":"10.1136\/bcr-2020-236013","article-title":"Rare case of primary leiomyosarcoma of the breast treated with wide local excision and planned cosmetic breast reduction surgery","volume":"13","author":"Horton","year":"2020","journal-title":"BMJ Case Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s13256-019-2197-2","article-title":"Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report","volume":"13","author":"Miyazaki","year":"2019","journal-title":"J Med Case Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2018.04.010","article-title":"Primary breast leiomyosarcoma with metastases to the lung in a young adult: case report and literature review","volume":"47","author":"Amberger","year":"2018","journal-title":"Int J Surg Case Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.10.98","article-title":"Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report","volume":"9","author":"Testori","year":"2017","journal-title":"J Thorac Dis"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.03.001","article-title":"Leiomyosarcoma of the breast: a case report and review of the literature about therapeutic management","volume":"20","author":"Fujita","year":"2011","journal-title":"Breast."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.108290","article-title":"Primary leiomyosarcoma of the breast: a case report and literature review","volume":"106","author":"Masadah","year":"2023","journal-title":"Int J Surg Case Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4103\/ijmpo.ijmpo_139_16","article-title":"Primary leiomyosarcoma of breast presenting with metastasis: an atypical presentation with dismal prognosis","volume":"38","author":"Singh","year":"2017","journal-title":"Indian J Med Paediatr Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000489866","article-title":"Pancreatic metastasis from primary leiomyosarcoma of the breast","volume":"26","author":"Felix","year":"2019","journal-title":"Ge Port J Gastroenterol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.12.050","article-title":"A rare etiology of a large tumoral mass of the breast - case report primary leiomyosarcoma and osteosarcoma of the breast","volume":"78","author":"Galama","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102495","article-title":"Leiomyosarcoma of the male breast: case report","volume":"67","author":"Ely","year":"2021","journal-title":"Ann Med Surg (Lond)."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2012.15.1.124","article-title":"Primary leiomyosarcoma of the breast: a case report","volume":"15","author":"Karabulut","year":"2012","journal-title":"J Breast Cancer."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S62349","article-title":"Isolation, detection, and immunomorphological characterization of circulating tumor cells (ctcs) from patients with different types of sarcoma using isolation by size of tumor cells: a window on sarcoma-cell invasion","volume":"7","author":"Chinen","year":"2014","journal-title":"Onco Targets Ther"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.242","article-title":"Positive response of a primary leiomyosarcoma of the breast following salvage hyperthermia and pazopanib","volume":"33","author":"Lee","year":"2018","journal-title":"Korean J Intern Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33475","article-title":"Initial experience using ultrasound, automated breast volume scanner, and elastography for primary leiomyosarcoma of the breast: a rare case report","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13190","article-title":"Leiomyosarcoma with osteoclast-like (lms-ogc) giant cells the breast: a report of a rare case","volume":"10","author":"Xu","year":"2019","journal-title":"Thorac Cancer."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2016.0253040117","article-title":"Leiomyoma of the breast parenchyma: a case report and review of the literature","volume":"136","author":"Brandao","year":"2018","journal-title":"Sao Paulo Med J"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12328","article-title":"Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: a case expressing receptor activator of nf-kappab ligand (rankl)","author":"Tajima","year":"2015","journal-title":"Pathol Int"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2015.06.014","article-title":"Primary breast leiomyosarcoma located in the premammary zone: a case report","volume":"39","author":"Kim","year":"2015","journal-title":"Clin Imaging."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1571029\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:25:44Z","timestamp":1747891544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1571029\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":21,"alternative-id":["10.3389\/fonc.2025.1571029"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1571029","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"article-number":"1571029"}}