{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:25:58Z","timestamp":1783607158353,"version":"3.55.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Synchronous multiple primary malignant neoplasms (MPMNs) involving distinct histopathological entities within the upper urinary tract represent a rare clinical phenomenon. We present a novel case of a 57-year-old male presenting with asymptomatic gross hematuria, subsequently diagnosed with three concurrent malignancies: papillary renal cell carcinoma(T1bN0M0), verrucous carcinoma of the renal pelvis (T1N0M0), and low-grade invasive urothelial carcinoma of the ureter (T2N0M0). Comprehensive imaging evaluation revealed a 5.7*5.2cm renal mass and 12cm ureteral tumor extending into the bladder. Following radical nephroureterectomy, histopathological confirmation of three distinct primary malignancies was achieved. Postoperative surveillance identified metastatic progression to adrenal, retroperitoneal, and peritoneal regions within four months, with subsequent development of bladder urothelial carcinoma. The unusual coexistence of three histologically distinct upper urinary tract malignancies, particularly the rare verrucous carcinoma variant, provides novel insights into tumor biology and clinical management paradigms for genitourinary MPMNs.<\/jats:p>","DOI":"10.3389\/fonc.2025.1576764","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T04:10:33Z","timestamp":1753330233000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multiple synchronous primary malignant neoplasms of renal, ureter and urinary bladder: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Bincheng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdulkarem","family":"Al-Qaisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaodan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i30.11146","article-title":"Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers): A case report","volume":"10","author":"Zhao","year":"2022","journal-title":"World J Clin cases"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1090634","article-title":"Multiple primary Malignant neoplasm: Case report and comprehensive literature review","volume":"12","author":"Ma","year":"2022","journal-title":"Front Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/b:urol.0000032673.34011.7d","article-title":"Multiple primary Malignant neoplasms in urologic patients","volume":"36","author":"Inci","year":"2004","journal-title":"Int Urol Nephrol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956519","article-title":"Successful first-line treatment of simultaneous multiple primary Malignancies of lung adenocarcinoma and renal clear cell carcinoma: A case report","volume":"13","author":"Ye","year":"2022","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/970293","article-title":"Stomach carcinoma presenting with a synchronous liver cancer: a case report and literature review","volume":"2014","author":"Wang","year":"2014","journal-title":"Case Rep Gastrointest Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0140","article-title":"Obesity, energy balance, and cancer: new opportunities for prevention","volume":"5","author":"Hursting","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-294","article-title":"Multiple primary Malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: a case report","volume":"12","author":"Mukaiyama","year":"2014","journal-title":"World J Surg Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_617_18","article-title":"Urothelial carcinoma of the renal pelvis with synchronous ipsilateral papillary renal cell carcinoma","volume":"63","author":"Bagga","year":"2020","journal-title":"Indian J Pathol Microbiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2017.17.e19","article-title":"Multiple primary Malignancies in patients with multiple early gastric cancer","volume":"17","author":"Kim","year":"2017","journal-title":"J Gastric Cancer"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081940","article-title":"Synchronous\/metachronous multiple primary Malignancies: review of associated risk factors","volume":"12","author":"Pan","year":"2022","journal-title":"Diagn (Basel)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65281-9","article-title":"Coincidence of bladder and prostate cancer","volume":"157","author":"Chun","year":"1997","journal-title":"J Urol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12885-019-6452-0","article-title":"The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study","volume":"20","author":"Feller","year":"2020","journal-title":"BMC Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1159\/000330906","article-title":"Verrucous carcinoma of the renal pelvis with a focus of conventional squamous cell carcinoma","volume":"88","author":"Baseskioglu","year":"2012","journal-title":"Urol Int"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00202204","article-title":"Verrucous carcinoma of the renal pelvis: case presentation and review of the literature","volume":"428","author":"Sheaff","year":"1996","journal-title":"Virchows Arch"},{"key":"B15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0090-4295(01)01133-5","article-title":"Verrucous carcinoma of the renal pelvis","volume":"58","author":"Kansal","year":"2001","journal-title":"Urology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/s0003-4401(01)00025-0","article-title":"Verrucous carcinoma of the kidney: report of 2 cases","volume":"35","author":"Sellami-Boudawara","year":"2001","journal-title":"Ann Urol (Paris)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.21037\/tau-21-47","article-title":"Update on systemic treatment of upper tract urothelial carcinoma: a narrative review of the literature","volume":"10","author":"Gust","year":"2021","journal-title":"Transl Androl Urol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1928-x","article-title":"Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)","volume":"35","author":"Soria","year":"2017","journal-title":"World J Urol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2022-0465","article-title":"Case report: Quadruple primary Malignant neoplasms including esophageal, ureteral, and lung in an elderly male","volume":"17","author":"Wan","year":"2022","journal-title":"Open Life Sci"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1576764\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:06:57Z","timestamp":1754996817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1576764\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":19,"alternative-id":["10.3389\/fonc.2025.1576764"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1576764","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"article-number":"1576764"}}