{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:25Z","timestamp":1753892065421,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To present a rare case of mediastinal extraosseous Ewing sarcoma(EES), broadening the body of knowledge already in existence on EES. This paper intends to give doctors more diagnostic and therapeutic understanding<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patient\u2019s imaging data was analyzed retrospectively. We identified and compiled the distinctive imaging characteristics of mediastinal EES by combining these results with histopathological evaluation and a review of relevant literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key findings<\/jats:title><jats:p>Typical imaging features of mediastinal EES include a large, bulky mass with irregular shape and lobulated, poorly defined margins. On computed tomography (CT), it often shows heterogeneous density along with infiltration of nearby organs and anatomical structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mediastinal EES is a rare and clinically challenging diagnosis. However, recognition of its characteristic imaging features may facilitate radiological diagnosis. Nevertheless, histopathological confirmation remains the gold standard for definitive diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1578456","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:12:01Z","timestamp":1750227121000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ewing\u2019s sarcoma of the mediastinal extraosseous site: a case report of a rare occurrence with literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Hong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Qi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Qian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1074378","article-title":"Extraskeletal Ewing\u2019s sarcoma of the mediastinum: Case report","volume":"13","author":"Caltavituro","year":"2023","journal-title":"Front Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.3390\/cancers12102927","article-title":"Primary Ewing sarcoma\/primitive neuroectodermal tumor of the kidney: the MD anderson cancer center experience","volume":"12","author":"Tarek","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1066304","DOI":"10.3389\/fsurg.2022.1066304","article-title":"A case of giant Ewing\u2019s sarcoma (EES)\/primitive neuroectodermal tumor (PNET) of the cervicothoracic junction in children with incomplete paralysis of both lower limbs: Case report and literature review","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1020339","DOI":"10.3389\/fonc.2022.1020339","article-title":"Case report: Primary mediastinal Ewing\u2019s sarcoma presenting with chest tightness","volume":"12","author":"Cui","year":"2022","journal-title":"Front Oncol"},{"year":"2025","author":"Durer","article-title":"Ewing sarcoma","key":"B5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24251","article-title":"Clinical features and outcomes in patients with secondary Ewing sarcoma","volume":"60","author":"Applebaum","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2019.03.16","article-title":"Primitive neuroectodermal tumors: a clinical and radiological analysis of six cases","volume":"9","author":"Liu","year":"2019","journal-title":"Quant Imaging Med Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210226","article-title":"Extraskeletal Ewing sarcoma from head to toe: multimodality imaging review","volume":"42","author":"Wright","year":"2022","journal-title":"Radiographics"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160095","article-title":"ITMIG classification of mediastinal compartments and multidisciplinary approach to mediastinal masses","volume":"37","author":"Carter","year":"2017","journal-title":"Radiographics"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008376","article-title":"Primary mediastinal large B-cell lymphoma","volume":"140","author":"Savage","year":"2022","journal-title":"Blood"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1578456\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:12:02Z","timestamp":1750227122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1578456\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":10,"alternative-id":["10.3389\/fonc.2025.1578456"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1578456","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"article-number":"1578456"}}