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A narrative review of the English language literature available in the PubMed and Embase databases from January 2010 to December 2024 was conducted to identify treatment methods and follow-up data for HNSCC metastatic to the parotid gland. This study provides a detailed overview of the histological and diagnostic imaging characteristics as well as the surgical and non-surgical procedures employed in the management of HNSCC metastases to the parotid gland. Furthermore, the management of CUP is outlined. The extent of the parotidectomy and concomitant neck dissection remains a topic of ongoing debate. The flow chart presented in this study may assist in decision-making regarding surgical treatment. Given that locoregional recurrence is the primary cause of mortality in HNSCC, surgical treatment is likely to be the most effective means of achieving a favorable outcome.<\/jats:p>","DOI":"10.3389\/fonc.2025.1579680","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:24:38Z","timestamp":1748323478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical management of head and neck squamous cell carcinoma metastatic to the parotid gland"],"prefix":"10.3389","volume":"15","author":[{"given":"Micha\u0142","family":"Gontarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Urba\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Bargiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"G\u0105siorowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Marecik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Wyszy\u0144ska-Pawelec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.010","article-title":"Delineation of the neck node levels for head and neck tumors: a 2013 update. 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