{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:58:00Z","timestamp":1767941880849,"version":"3.49.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["\u7f16\u53f7 821RC677, ZDKJ2021042, LY21H080005"],"award-info":[{"award-number":["\u7f16\u53f7 821RC677, ZDKJ2021042, LY21H080005"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Adenomatoid tumors (ATs) are benign tumors commonly found in the genital organs, usually occurring as a single mass with a good prognosis after surgery. However, multiple extragenital ATs are extremely rare, often asymptomatic, and may lead to misdiagnosis. This case report describes a patient with multiple ATs involving the rectum and small intestinal mesentery. The patient was a 39-year-old man who had been suffering from abdominal pain and recurrent loose stools for 6 months. Diagnostic contrast-enhanced computed tomography (DCE-CT) of the abdomen and pelvis showed multiple cystic\u2013solid masses with uneven density and patchy enhancement at the edges. The patient underwent laparoscopic total excision, and postoperative pathology confirmed multiple extragenital ATs in the rectum and small intestinal mesentery. The patient recovered well, and no recurrence was observed during a 17-month follow-up. This case aims to raise awareness of the imaging features of multiple ATs in rare extragenital locations, preventing misdiagnosis, missed diagnosis, and excessive treatment.<\/jats:p>","DOI":"10.3389\/fonc.2025.1581770","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:14:55Z","timestamp":1767935695000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Multiple extragenital adenomatoid tumors in the rectum and small intestinal mesentery"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhongqian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xiaoyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"B1","first-page":"573","article-title":"Lymphangioma of the Fallopian tube: with three illustrations","volume":"65","author":"Leighton","year":"1912","journal-title":"Am J Obstet Dis Women Child"},{"key":"B2","first-page":"63","article-title":"Adenomatoid tumors of the genital tract","volume":"21","author":"Golden","year":"1945","journal-title":"Am J Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711480409","article-title":"Adenomatoid tumours: an immunohistochemical and ultrastru ctural appraisal of their histogenesis","volume":"148","author":"Stephenson","year":"1986","journal-title":"J Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.153","article-title":"Adenom atoid tumors of the male and female genital tract are defined by TRAF7 mutations th at drive aberrant NF-kB pathway activation","volume":"31","author":"Goode","year":"2018","journal-title":"Mod Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.humpath.2021.02.007","article-title":"TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with Malignant mesothelioma","volume":"111","author":"Itami","year":"2021","journal-title":"Hum Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/his.14387","article-title":"L1CAM expression in cystic mesothelial lesions: a comparison with adenomatoid tumours, w ell-differentiated papillary mesothelial tumours and Malignant mesotheliomas","volume":"79","author":"Karpathiou","year":"2021","journal-title":"Histopathology"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914537680","article-title":"Adenomatoid tumor of the small intestine: the first case report and r eview of the literature","volume":"22","author":"Lao","year":"2014","journal-title":"Int J Surg Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.692553","article-title":"Adenomatoid tumor of the adrenal gland: report of two cases and review of the literature","volume":"23","author":"Guan","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11748-014-0419-5","article-title":"Adenomatoid tumor of the mediastinum","volume":"64","author":"Goto","year":"2016","journal-title":"Gen Th orac Cardiovasc Surg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035386","article-title":"Multiple adenom atoid tumours in the liver and peritoneum","volume":"60","author":"Hayes","year":"2007","journal-title":"J Clin Pathol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2008.01084.x","article-title":"Multiple extragenital adenomatoid tumors in the mesocolon and omentum","volume":"116","author":"Yeh","year":"2008","journal-title":"APMIS"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1581770\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:14:57Z","timestamp":1767935697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1581770\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":11,"alternative-id":["10.3389\/fonc.2025.1581770"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1581770","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"article-number":"1581770"}}