{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:07:46Z","timestamp":1781572066928,"version":"3.54.5"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to evaluate whether opioid-free anesthesia is non-inferior to opioid-based anesthesia in terms of short-term recovery quality in patients undergoing laparoscopic-assisted colorectal tumor resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized controlled trial was conducted with 102 participants, who were randomly assigned to one of two groups: opioid-free general anesthesia with thoracic epidural anesthesia (OFA) group and opioid-based general anesthesia with compound transversalis fascia nerve block (OA) group. The primary observation outcomes were the preoperative and postoperative Quality of Recovery-40 (QoR-40) questionnaire scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were observed in preoperative or postoperative QoR-40 scores between the two groups (<jats:italic>p<\/jats:italic> = 0.05). However, the OFA group demonstrated a significantly longer recovery time in the recovery room compared to the OA group (<jats:italic>p<\/jats:italic>&amp;lt; 0.05). No significant differences were observed between the two groups in postoperative nausea and vomiting, time to first meal after surgery, postoperative drainage tube removal time, postoperative sufentanil dose, or postoperative 24-hour numerical rating scale (<jats:italic>p<\/jats:italic> &amp;gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Opioid-free general anesthesia is not superior to opioid-based general anesthesia with transversalis fascia nerve block in terms of short-term postoperative recovery quality following laparoscopic-assisted colorectal tumor resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:uri>https:\/\/www.chictr.org.cn\/<\/jats:uri>, identifier 2023-12-08.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1588623","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:14:43Z","timestamp":1751429683000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of opioid-free anesthesia in short-term recovery following laparoscopic-assisted colorectal tumor resection: a randomized 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