{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:02:40Z","timestamp":1764349360154,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Subhepatic appendicitis complicated by hepatic abscess is an uncommon clinical condition due to anatomical variations in the appendix\u2019s position. Here, we report an unusual case of a 56-year-old male who initially presented with right abdominal pain and fever, misdiagnosed as bilateral kidney stones and urinary tract infection. Subsequent abdominal CT(Computed Tomography) scans revealed subhepatic appendicitis with a hepatic abscess located in segment VI of the liver. The patient underwent successful laparoscopic appendectomy and hepatic abscess drainage. Unexpectedly, histopathological examination of the appendix demonstrated diffuse large B-cell lymphoma (DLBCL), a rare form of primary appendiceal non-Hodgkin lymphoma. Immunohistochemistry confirmed the diagnosis, with tumor cells positive for CD20, CD79a, Bcl-6, and c-Myc, and a high Ki-67 proliferative index (&amp;gt;90%). This case highlights the diagnostic challenges associated with atypically positioned appendicitis and underscores the importance of pathological evaluation in detecting rare underlying malignancies.<\/jats:p>","DOI":"10.3389\/fonc.2025.1591905","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:23:35Z","timestamp":1750051415000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported 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