{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:40:53Z","timestamp":1773729653284,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Paragangliomas (PGLs) are rare neuroendocrine tumors originating from chromaffin cells. The synchronous occurrence of bladder and retroperitoneal PGLs is extremely rare. This case highlights the radiological features of dual-site PGLs and their potential for misdiagnosis as bladder cancer with retroperitoneal lymph node metastasis. A 59-year-old female patient was admitted with a 2-week history of abdominal distention. Imaging showed a highly vascularized 1.3 cm \u00d7 1.2 cm nodule on the right wall of the bladder and a retroperitoneal mass measuring 1.8 cm \u00d7 3.7 cm adjacent to the left side of the abdominal aorta. Postoperative pathological examination confirmed dual-site PGLs. The multifocal appearance and hypervascular characteristics of these tumors may lead to misdiagnosis as bladder cancer with metastasis. Recognizing the clinical, imaging (such as CT and MRI findings), and pathological features is crucial for avoiding misdiagnosis and formulating an appropriate treatment plan.<\/jats:p>","DOI":"10.3389\/fonc.2025.1593934","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T04:16:16Z","timestamp":1755058576000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Synchronous bladder and retroperitoneal paragangliomas: an extremely rare entity"],"prefix":"10.3389","volume":"15","author":[{"given":"Weitao","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/ases.13124","article-title":"Retroperitoneoscopic resection of a primary retroperitoneal paraganglioma occurring between the aorta and vena cava: A case report","volume":"16","author":"Nishikimi","year":"2022","journal-title":"Asian J Endosc Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2017.03.010","article-title":"Paraganglioma of the urinary bladder: A series of 22 cases in a single center","volume":"15","author":"Zhai","year":"2017","journal-title":"Clin Genitourin Canc"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2019.100950","article-title":"A rare case of non\u2013functioning bladder paraganglioma treated with robotic assisted partial cystectomy","volume":"26","author":"Alanee","year":"2019","journal-title":"Urol Case Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"492","DOI":"10.2214\/AJR.05.0370","article-title":"Extraadrenal paragangliomas of the body: imaging features","volume":"187","author":"Lee","year":"2006","journal-title":"Am J Roentgenol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/11156.5570","article-title":"Non\u2013functional paraganglioma of retroperitoneum mimicking pancreatic mass with concurrent urinary bladder paraganglioma: an extremely rare entity","volume":"9","author":"Verma","year":"","journal-title":"J Clin Diagn Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2017.1182","article-title":"Paraganglioma of the bladder in a kidney transplant recipient: A case report","volume":"6","author":"Lazareth","year":"2017","journal-title":"Mol Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/cen.15058","article-title":"Diagnosis and management of urinary bladder paragangliomas: A Sino\u2013American\u2013European retrospective observational study","volume":"101","author":"Pang","year":"2024","journal-title":"Clin Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20138587(23)00256\u20135","article-title":"Catecholamine\u2013induced hypertensive crises: current insights and management","volume":"11","author":"Nazari","year":"2023","journal-title":"Lancet Diabetes Endo"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2013021\u201303851\u2013x","article-title":"Differences in clinical presentation and management between pre\u2013 and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? 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