{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:17:18Z","timestamp":1793042238191,"version":"4.5.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Breast cancer is one of the most common malignant tumors in women. Most early-stage breast cancer does not have the typical symptoms and signs. The common metastatic sites of breast cancer are bones, lymph nodes, soft tissues, lungs, brain, liver. Cases with the gastrointestinal (GI) tract as the first site of metastasis are relatively rare. Their clinical, imaging, and gastroscopic manifestations lack specificity, making them difficult to distinguish from primary gastric cancer. A 45-year-old woman presented with a week-long history of black stools, later diagnosed as gastric metastasis from breast cancer. The patient had undergone surgery, radiotherapy, and chemotherapy 18 years prior for left invasive lobular carcinoma (ILC) of the breast. Current symptoms included black stools, hiccups, fatigue, and decreased appetite, with no nausea, fever, or chills. Gastroscopy revealed a gastric ulcer, and biopsy confirmed poorly differentiated gastric adenocarcinoma. PET-CT indicated high metabolism in the stomach but no distant metastasis. A total gastrectomy with lymph node dissection revealed tumor invasion of the serosal membrane and nerves, confirming metastatic breast cancer. Postoperative treatment and follow-up showed no recurrence or metastasis, and the patient remained stable. Gastric metastasis from breast cancer is an uncommon condition, mostly associated with invasive lobular carcinoma. Accurate diagnosis requires careful consideration of the patient\u2019s medical history and a comprehensive approach utilizing clinical manifestations, imaging, endoscopy, histopathology, and immunohistochemistry (IHC) to minimize the risk of missed or incorrect diagnoses. Treatment remains centered on systemic therapies, including chemotherapy and endocrine therapy.<\/jats:p>","DOI":"10.3389\/fonc.2025.1596207","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T04:10:53Z","timestamp":1753330253000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Breast cancer with gastric metastasis in invasive lobular carcinoma: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Bing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.02.002","article-title":"Translational adaptation in breast cancer metastasis and emerging therapeutic opportunities","volume":"45","author":"Chen","year":"2024","journal-title":"Trends Pharmacol Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.65852","article-title":"Gastrointestinal metastases from lobular breast carcinoma: A literature review","volume":"16","author":"Kioleoglou","year":"2024","journal-title":"Cureus"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1356167","article-title":"Case report: Cutaneous metastases as a first manifestation from breast cancer with concurrent gastric metastases","volume":"15","author":"Xu","year":"2024","journal-title":"Front Pharmacol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.010","article-title":"5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)","volume":"31","author":"Cardoso","year":"2020","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35288","article-title":"Breast cancer therapy in China: Introducing the Special Collection","volume":"130","author":"Wang","year":"2024","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091","article-title":"The 2019 World Health Organization classification of tumours of the breast","volume":"77","author":"Tan","year":"2020","journal-title":"Histopathology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.033","article-title":"Comprehensive molecular portraits of invasive lobular breast cancer","volume":"163","author":"Ciriello","year":"2015","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022527","article-title":"Widespread Metastasis to the Stomach 10 Years After Primary Breast Cancer: A case report and review of the literature","volume":"99","author":"Fu","year":"2020","journal-title":"Med (Baltimore)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i38.6219","article-title":"Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature","volume":"12","author":"Nazareno","year":"2006","journal-title":"World J Gastroenterol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1013066","article-title":"Case Report: 68Ga-FAPI PET\/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.2019194003","article-title":"68Ga FAPI PET\/CT: tracer uptake in 28 different kinds of cancer","volume":"1","author":"Hathi","year":"2019","journal-title":"Radiol Imaging Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_453_21","article-title":"GATA Binding Protein 3 (GATA-3) expression evaluation as prognostic factor in breast cancer and its relationship with other immunemarkers","volume":"66","author":"Tabriz","year":"2023","journal-title":"Indian J Pathol Microbiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03478-2","article-title":"Well-differentiated neuroendocrine tumor of the urinary bladder expressing GATA 3","volume":"482","author":"Marletta","year":"2023","journal-title":"Virchows Arch Int J Pathol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000001160","article-title":"HepPar1 and GATA-3 expression in neuroendocrine neoplasms: A potential trap for pathologic diagnosis","volume":"31","author":"Xu","year":"2023","journal-title":"Appl Immunohistochem Mol Morphol AIMM"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/annonc\/mdz189","article-title":"ESMO Guidelines Committee. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"30","author":"Cardoso","year":"2019","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/jso.23945","article-title":"Metastatic gastric cancer (MGC) patients: Can we improve survival by metastasectomy? A systematic review and meta-analysis","volume":"112","author":"Gadde","year":"2015","journal-title":"J Surg Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2017.1369379","article-title":"Metastasis to the pancreas and stomach from a breast cancer primary: a case report","volume":"7","author":"Kliiger","year":"2017","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/03000605241233988","article-title":"Gastric metastasis from breast cancer: five cases and a single-institutional review","volume":"52","author":"Cheng","year":"2024","journal-title":"J Int Med Res"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1596207\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T04:10:54Z","timestamp":1753330254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1596207\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":19,"alternative-id":["10.3389\/fonc.2025.1596207"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1596207","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"article-number":"1596207"}}