{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:02:43Z","timestamp":1765962163469,"version":"3.48.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Signaling pathways associated with spasmolytic polypeptide-expressing metaplasia (SPEM) pathogenesis play a critical role in disease development, particularly in gastric cancer precursor lesions. However, global research trends in signaling pathways in SPEM pathogenesis remain undetermined. This study aims to fill this gap by conducting a comprehensive bibliometric analysis to map the field, identify key insights, and guide future research directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Articles and reviews were retrieved from the Web of Science Core Collection up to June 8 2025. Bibliometric analysis and knowledge mapping were conducted via CiteSpace and VOSviewer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 89 papers from 221 institutions, 719 authors, and 56 journals across 21 countries\/regions were included. The number of publications is growing slowly.\n                      <jats:italic>Gastroenterology<\/jats:italic>\n                      led in publication and co-citation counts. The United States and China were at the top in terms of publication numbers. Goldenring JR emerged as the most co-cited and most published author. Key findings indicate limited collaboration despite a foundation of ten pivotal articles. Research elucidating gene-pathway interplay and cytokine roles in SPEM pathogenesis has consequently sharpened the focus on developing pharmacological agents that target these pathways, defining a pivotal new direction for combating gastric precancerous lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By systematically reviewing signaling pathways in SPEM pathogenesis, this study provides critical guidance for future research strategic planning and collaboration. It highlights the urgent need for strengthened interdisciplinary and global partnerships to drive progress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1597221","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:56:54Z","timestamp":1765961814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a bibliometric analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Qiumiao","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112152-20240119-00035","article-title":"Cancer incidence and mortality in China, 2022","volume":"46","author":"Zheng","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"B3","first-page":"1","article-title":"Biological agents","volume":"100","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"B4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-023-00431-8","article-title":"Helicobacter pylori infection","volume":"9","author":"Malfertheiner","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-47331-9_1","article-title":"Gastric stem cell biology and helicobacter pylori infection","volume-title":"Helicobacter pylori and Gastric Cancer","author":"Wizenty","year":"2023"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-025-03960-8","article-title":"Myeloid-derived suppressor cells modulation in the context of tumor microenvironment for gastric cancer","volume":"27","author":"Portillo-Mi\u00f1o","year":"2025","journal-title":"Clin Trans Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1007468","DOI":"10.1371\/journal.ppat.1007468","article-title":"Increased programmed death-ligand 1 is an early epithelial cell response to helicobacter pylori infection","volume":"15","author":"Holokai","year":"2019","journal-title":"PloS Pathog"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03793-6","article-title":"Global lifetime estimates of expected and preventable gastric cancers across 185 countries","volume":"31","author":"Park","year":"2025","journal-title":"Nat Med"},{"key":"B9","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2013First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1053\/j.gastro.2023.08.028","article-title":"Gastric intestinal metaplasia: real culprit or innocent bystander as a precancerous condition for gastric cancer","volume":"165","author":"Sugano","year":"2023","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-24\u2013508","article-title":"Emerging role of spasmolytic polypeptide-expressing metaplasia in gastric cancer","volume":"15","author":"Ye","year":"2024","journal-title":"J Gastrointest Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00591\u20130","article-title":"The immune microenvironment in gastric adenocarcinoma","volume":"19","author":"Zavros","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0198-5","article-title":"Autoimmune gastritis","volume":"6","author":"Lenti","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B14","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1007\/s11938-020-00298-8","article-title":"Gastritis: an update in 2020","volume":"18","author":"Rugge","year":"2020","journal-title":"Curr Treat Options Gastroenterol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"117062","DOI":"10.1016\/j.jep.2023.117062","article-title":"Efficacy and potential therapeutic mechanism of Weiwei decoction on Spasmolytic polypeptide-expressing metaplasia in Helicobacter pylori-infected and Atp4a-knockout mice","volume":"319","author":"Hong","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.036","article-title":"Cellular plasticity, reprogramming, and regeneration: metaplasia in the stomach and beyond","volume":"162","author":"Goldenring","year":"2022","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021\u2013325310","article-title":"Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa","volume":"71","author":"Caldwell","year":"2022","journal-title":"Gut"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112660","article-title":"Expression alteration and dysfunction of ion channels\/transporters in the parietal cells induces gastric diffused mucosal injury","volume":"148","author":"Zhao","year":"2022","journal-title":"BioMed Pharmacother"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.devcel.2024.03.002","article-title":"Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway","volume":"59","author":"Miao","year":"2024","journal-title":"Dev Cell"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/jp275512","article-title":"Injury, repair, inflammation and metaplasia in the stomach","volume":"596","author":"Meyer","year":"2018","journal-title":"J Physiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/advs.202401227","article-title":"H. Pylori-facilitated TERT\/wnt\/\u03b2-catenin triggers spasmolytic polypeptide-expressing metaplasia and oxyntic atrophy","volume":"12","author":"He","year":"2024","journal-title":"Adv Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102063","article-title":"Metaplasia in the stomach-precursor of gastric cancer","volume":"18","author":"Kinoshita","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115\u2013105447","article-title":"Trefoil factor peptides and gastrointestinal function","volume":"79","author":"Aihara","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3892\/ijo.2024.5621","article-title":"Role and research progress of spasmolytic polypeptide\u2212expressing metaplasia in gastric cancer (Review)","volume":"64","author":"Chong","year":"2024","journal-title":"Int J Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S516605","article-title":"Proteomic landscape of small extracellular vesicles derived from gastric juice and identified TFF2 as a specific biomarker","volume":"20","author":"Fan","year":"2025","journal-title":"Int J Nanomed"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12320","article-title":"Serum Level of Trefoil Factor 2 can Predict the Extent of Gastric Spasmolytic Polypeptide-Expressing Metaplasia in the H. pylori-Infected Gastric Cancer Relatives","volume":"22","author":"Kuo","year":"2017","journal-title":"Helicobacter"},{"key":"B27","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/s41420-024-02275-x","article-title":"The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer","volume":"10","author":"Yan","year":"2024","journal-title":"Cell Death Discov"},{"key":"B28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41419-024-07318-w","article-title":"Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE","volume":"16","author":"Liu","year":"2025","journal-title":"Cell Death Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202401227","article-title":"H. Pylori-facilitated TERT\/wnt\/\u03b2-catenin triggers spasmolytic polypeptide-expressing metaplasia and oxyntic atrophy","volume":"12","author":"He","year":"2025","journal-title":"Adv Sci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41420-025-02289-z","article-title":"Helicobacter pylori reduces METTL14-mediated VAMP3 m(6)A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling","volume":"11","author":"Cui","year":"2025","journal-title":"Cell Death Discov"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1113\/jp277259","article-title":"Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids","volume":"597","author":"Engevik","year":"2019","journal-title":"J Physiol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01133\u20137","article-title":"Processing stimulus dynamics by the NF-\u03baB network in single cells","volume":"55","author":"Son","year":"2023","journal-title":"Exp Mol Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188362","article-title":"Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications","volume":"1873","author":"Jahan","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B34","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.gie.2021.02.006","article-title":"Has the issue of the \u201cpoint of no return\u201d in gastric carcinogenesis already been resolved","volume":"94","author":"Nishida","year":"2021","journal-title":"Gastrointest Endosc"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094909","article-title":"Trefoil factor family (TFF) peptides and their links to inflammation: A re-evaluation and new medical perspectives","volume":"22","author":"Hoffmann","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B36","doi-asserted-by":"crossref","DOI":"10.1109\/ICTEI60496.2023.00021","article-title":"Application research of image processing and visualization thchnology in gastric mucosal protective factors using artificial intelligence","author":"Xu","year":"2023"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaf030","article-title":"Chemoprevention strategies for precancerous gastric lesions beyond helicobacter pylori eradication","volume":"118","author":"Zhang","year":"2025","journal-title":"Qjm"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021\u2013326483","article-title":"Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities","volume":"72","author":"Ho","year":"2023","journal-title":"Gut"},{"key":"B39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41568-021-00412\u20137","article-title":"Mapping the genomic diaspora of gastric cancer","volume":"22","author":"Yeoh","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/asi.20317","article-title":"CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J Am Soc Inf Sci Technol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/publications11010010","article-title":"Exploratory bibliometrics: using VOSviewer as a preliminary research tool","volume":"11","author":"Kirby","year":"2023","journal-title":"Publications"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipm.2021.102594","article-title":"Detecting research topic trends by author-defined keyword frequency","volume":"58","author":"Lu","year":"2021","journal-title":"Inf Process Manage"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/asi.21419","article-title":"Co-citation analysis, bibliographic coupling, and direct citation: Which citation approach represents the research front most accurately","volume":"61","author":"Boyack","year":"2010","journal-title":"J Am Soc Inf Sci Technol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1128\/iai.02039-05","article-title":"Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses","volume":"75","author":"Kurt-Jones","year":"2007","journal-title":"Infect Immun"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.049","article-title":"Expression of activated ras in gastric chief cells of mice leads to the full spectrum of metaplastic lineage transitions","volume":"150","author":"Choi","year":"2016","journal-title":"Gastroenterology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804935200","article-title":"Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines","volume":"284","author":"Dubeykovskaya","year":"2009","journal-title":"J Biol Chem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jep.2023.117075","article-title":"Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia","volume":"318","author":"Xiong","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.prp.2023.154699","article-title":"Correlation of Claudin18.2 expression with clinicopathological characteristics and prognosis in gastric cancer","volume":"248","author":"Tao","year":"2023","journal-title":"Pathol Res Pract"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.03.003","article-title":"Deficiency of stomach-type claudin-18 in mice induces gastric tumor formation independent of H pylori infection","volume":"8","author":"Suzuki","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.597757","article-title":"Human Trefoil Factor 2 Is a Lectin That Binds \u03b1-GlcNAc-capped Mucin Glycans with Antibiotic Activity against Helicobacter pylori","volume":"289","author":"Hanisch","year":"2014","journal-title":"J Biol Chem"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.9.1297","article-title":"Tumour necrosis factor \u03b1 and nuclear factor \u03baB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide","volume":"52","author":"Loncar","year":"2003","journal-title":"Gut"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101521","article-title":"Stratifin is necessary for spasmolytic polypeptide-expressing metaplasia development after acute gastric injury","volume":"19","author":"Won","year":"2025","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116070","article-title":"Cathartocytosis: Jettisoning of cellular material during reprogramming of differentiated cells","volume":"44","author":"Brown","year":"2025","journal-title":"Cell Rep"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1101\/2025.04.09.647847","article-title":"Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia\/SPEM following injury","author":"Tu","year":"2025","journal-title":"bioRxiv"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.040","article-title":"Interleukin 33 triggers early eosinophil-dependent events leading to metaplasia in a chronic model of gastritis-prone mice","volume":"160","author":"De Salvo","year":"2021","journal-title":"Gastroenterology"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/pin.70020","article-title":"Cmtm4 deficiency inhibits helicobacter pylori-induced gastric carcinogenesis","volume":"13","author":"Lang","year":"2025","journal-title":"Pathol Int"},{"key":"B57","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.celrep.2023.113497","article-title":"YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration","volume":"42","author":"Loe","year":"2023","journal-title":"Cell Rep"},{"key":"B58","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2023.03.024","article-title":"Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS)-NRF2-Heme oxygenase-1(HO-1)-NF-\u03baB axis","volume":"202","author":"Zeng","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2019.06.003","article-title":"Downregulation of notch signaling in kras-induced gastric metaplasia","volume":"21","author":"Chung","year":"2019","journal-title":"Neoplasia"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00325.2016","article-title":"NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus","volume":"312","author":"Demitrack","year":"2017","journal-title":"Am J Physiol-Gastroint Liver Physiol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205760","article-title":"Integrated multi-omics analysis and machine learning identify hub genes and potential mechanisms of resistance to immunotherapy in gastric cancer","volume":"16","author":"Wang","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.47","article-title":"Gastric tumor development in Smad3-deficient mice initiates from forestomach\/glandular transition zone along the lesser curvature","volume":"92","author":"Nam","year":"2012","journal-title":"Lab Invest"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.11.001","article-title":"Murine models of gastric corpus preneoplasia","volume":"3","author":"Petersen","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798311","article-title":"Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis","volume":"37","author":"Willet","year":"2018","journal-title":"EMBO J"},{"key":"B65","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1053\/j.gastro.2019.09.037","article-title":"Proliferation and differentiation of gastric mucous neck and chief cells during homeostasis and injury-induced metaplasia","volume":"158","author":"Burclaff","year":"2020","journal-title":"Gastroenterology"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019\u2013320368","article-title":"Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603782","article-title":"De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis","volume":"96","author":"El-Zaatari","year":"2007","journal-title":"Br J Cancer"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.08.017","article-title":"Transgenic expression of interferon-\u03b3 in mouse stomach leads to inflammation, metaplasia, and dysplasia","volume":"181","author":"Syu","year":"2012","journal-title":"Am J Pathol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"101026","DOI":"10.1016\/j.gendis.2023.04.042","article-title":"The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities","volume":"11","author":"Yu","year":"2024","journal-title":"Genes Dis"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00176.2010","article-title":"Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells","volume":"300","author":"Maloum","year":"2011","journal-title":"Am J Physiol-Gastroint Liver Physiol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.01.007","article-title":"Regulation of gastric lgr5+ve cell homeostasis by bone morphogenetic protein (BMP) signaling and inflammatory stimuli","volume":"5","author":"Ye","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.118","article-title":"Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing","volume":"398","author":"Zhang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9050715","article-title":"Activation of signal transduction and activator of transcription 3 signaling contributes to helicobacter-associated gastric epithelial proliferation and inflammation","volume":"2018","author":"Ishii","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00304.2018","article-title":"Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations","volume":"316","author":"Buzzelli","year":"2019","journal-title":"Am J Physiol-Gastroint Liver Physiol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.016","article-title":"DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia","volume":"160","author":"Miao","year":"2021","journal-title":"Gastroenterology"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.06.001","article-title":"Elevated protein kinase A activity in stomach mesenchyme disrupts mesenchymal-epithelial crosstalk and induces preneoplasis","volume":"14","author":"Puri","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.075","article-title":"Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation","volume":"161","author":"Busada","year":"2021","journal-title":"Gastroenterology"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1139391","article-title":"Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases","volume":"14","author":"Ding","year":"2023","journal-title":"Front Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019\u2013318930","article-title":"Single-cell transcriptional analyses of spasmolytic polypeptide-expressing metaplasia arising from acute drug injury and chronic inflammation in the stomach","volume":"69","author":"Bockerstett","year":"2020","journal-title":"Gut"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113236","article-title":"Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach","volume":"42","author":"Tsubosaka","year":"2023","journal-title":"Cell Rep"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e12891","DOI":"10.1111\/hel.12891","article-title":"Gastric organoids: Advancing the study of H. pylori pathogenesis and inflammation","volume":"27","author":"Idowu","year":"2022","journal-title":"Helicobacter"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e2413019","DOI":"10.1002\/advs.202413019","article-title":"Dissecting the spatial and single-cell transcriptomic architecture of cancer stem cell niche driving tumor progression in gastric cancer","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (Weinh)"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1597221\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:56:57Z","timestamp":1765961817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1597221\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":83,"alternative-id":["10.3389\/fonc.2025.1597221"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1597221","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"article-number":"1597221"}}