{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:53:18Z","timestamp":1782485598343,"version":"3.54.5"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate cancer, the most prevalent male malignancy in Western countries, seldom presents as secondary rectal linitis plastica (RLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We present an 82-year-old man with a 6-month history of altered bowel habits, narrowed stools, and mucous discharge, with absent lower urinary tract symptoms. Serum Prostate Specific Antigen (PSA) was markedly elevated (392 ng\/mL). Imaging demonstrated circumferential rectal thickening and a prostatic mass invading the bladder. MRI revealed a \u201ctarget sign\u201d with associated diffusion restriction. Colonoscopy identified circumferential mucosal protrusions resembling grape-like clusters (Nice Band Imaging (NBI) International Colorectal Endoscopic (NICE) type 3). Deep biopsies confirmed prostatic adenocarcinoma (Gleason score 4 + 3 = 7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnosis<\/jats:title><jats:p>A multidisciplinary team confirmed the diagnosis of prostate cancer with secondary RLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Treatment<\/jats:title><jats:p>Combination therapy (prophylactic colostomy, leuprorelin, and abiraterone) reduced PSA from 392 to 2.16 ng\/mL within 8 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RLP may mimic various gastrointestinal disorders clinically. Clinicians should consider RLP in elderly men presenting with gastrointestinal symptoms. Definitive diagnosis requires the integration of multi-modality imaging, endoscopy, and histopathological biopsy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1597367","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:35:53Z","timestamp":1753248953000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prostate cancer inducing secondary linitis plastica of the rectum: a rare case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Dongpo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daixiang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1166-7087(08)74567-6","article-title":"Les sites m\u00e9tastatiques atypiques des cancers de la prostate [Rare locations of metastases from prostate cancer","volume":"7","author":"Lebret","year":"2008","journal-title":"Prog Urol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjae046","article-title":"Prostate carcinoma mimicking rectal cancer: a case report","volume":"2024","author":"Hassine","year":"2024","journal-title":"J Surg Case Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v16.i9.473","article-title":"Secondary rectal linitis plastica caused by prostatic adenocarcinoma - magnetic resonance imaging findings and dissemination pathways: A case report","volume":"16","author":"Labra","year":"2024","journal-title":"World J Radiol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0050","article-title":"Prostate cancer, version 4.2023, NCCN clinical practice guidelines in oncology","volume":"21","author":"Schaeffer","year":"2023","journal-title":"J Natl Compr Canc Netw"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004476","article-title":"68 ga-PSMA-11 PET\/CT and PET\/MRI in rectal linitis plastica secondary to prostate adenocarcinoma","volume":"48","author":"Zhao","year":"2023","journal-title":"Clin Nucl Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_188_20","article-title":"Linitis plastica of the rectum secondary to metastatic prostate cancer: A case report of a rare presentation and literature review","volume":"13","author":"Khor","year":"2021","journal-title":"Urol Ann"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-248462","article-title":"Linitis plastica of the rectum secondary to prostate carcinoma","volume":"15","author":"Mommersteeg","year":"2022","journal-title":"BMJ Case Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102788","article-title":"Dual-time point [68 Ga]Ga-PSMA-11 PET\/CT hybrid imaging for staging and restaging of prostate cancer","volume":"12","author":"Hoffmann","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06353-y","article-title":"Comparison between pelvic PSMA-PET\/MR and whole-body PSMA-PET\/CT for the initial evaluation of prostate cancer: a proof of concept study","volume":"30","author":"Domachevsky","year":"2020","journal-title":"Eur Radiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-017-0599-2","article-title":"Clinicopathological study of 9 cases of prostate cancer involving the rectal wall","volume":"12","author":"Tang","year":"2017","journal-title":"Diagn Pathol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1597367\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:35:53Z","timestamp":1753248953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1597367\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":11,"alternative-id":["10.3389\/fonc.2025.1597367"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1597367","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"article-number":"1597367"}}