{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:46Z","timestamp":1753891906173,"version":"3.41.2"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Precise screening and discriminating of prostatic hyperplasia (PH) could avoid unnecessary biopsy and overdiagnosis. However, the metabolic pattern of patients with prostatic hyperplasia in Chinese population is rarely reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urine samples of Chinese participants with prostate cancer (PCa), benign prostatic hyperplasia (BPH) and non-prostate diseases (NPD) were detected with four ultra-performance liquid chromatography\/tandem mass spectrometric (UPLC-MS\/MS) methods to profile the metabolic disturbance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with PH, the most significant dysregulation was observed in metabolites categorized as lipid or amino acid, especially those involved in histidine metabolism, purine metabolism, tryptophan metabolism and tyrosine metabolism. For discrimination BPH from PCa, apart from previously reported metabolites related to phospholipid metabolism or tryptophan metabolism, metabolites of dipeptides and androgenic steroids, such as leucylhydroxyproline and etiocholanolone glucuronide, also exhibited potential to discriminate PCa from BPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study conducts precise detection of urinary metabolomic pattern for patients with benign prostatic hyperplasia or prostate cancer, and could inform their potential application as discriminant biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1604169","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T05:25:38Z","timestamp":1750829138000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants"],"prefix":"10.3389","volume":"15","author":[{"given":"Chenye","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruilin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1186\/s12885-022-10244-9","article-title":"Secular trends of morbidity and mortality of prostate, bladder, and kidney cancers in China 1990 to 2019 and their predictions to 2030","volume":"22","author":"Huang","year":"2022","journal-title":"BMC Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0050","article-title":"Prostate cancer, version 4.2023, NCCN clinical practice guidelines in oncology","volume":"21","author":"Schaeffer","year":"2023","journal-title":"J Natl Compr Canc Netw"},{"key":"B4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate cancer-2024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur Urol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMms1914228","article-title":"Reconsidering prostate cancer mortality - the future of PSA screening","volume":"382","author":"Welch","year":"2020","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2018.41","article-title":"Prostate cancer: Solo PSA test does not lower mortality","volume":"15","author":"Kelsey","year":"2018","journal-title":"Nat Rev Urol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2004.0020","article-title":"Prostate biopsy strategies: current state of the art","volume":"2","author":"Mian","year":"2004","journal-title":"J Natl Compr Canc Netw"},{"key":"B8","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3892\/ol.2023.13959","article-title":"Prostate biopsy approach and complication rates","volume":"26","author":"Mate","year":"2023","journal-title":"Oncol Lett"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04041.x","article-title":"Molecular genetics of prostate cancer: emerging appreciation of genetic complexity","volume":"60","author":"Barbieri","year":"2012","journal-title":"Histopathology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/ijc.34949","article-title":"Exploring the tumor genomic landscape of aggressive prostate cancer by whole-genome sequencing of tissue or liquid biopsies","volume":"155","author":"Weiss","year":"2024","journal-title":"Int J Cancer"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0097","article-title":"A novel urine exosome gene expression assay to predict high-grade prostate cancer at initial biopsy","volume":"2","author":"McKiernan","year":"2016","journal-title":"JAMA Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s12885-024-11819-4","article-title":"Diagnostic potential of exosomal extracellular vesicles in oncology","volume":"24","author":"Andre","year":"2024","journal-title":"BMC Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2015.1069711","article-title":"Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer","volume":"15","author":"Lucarelli","year":"2015","journal-title":"Expert Rev Mol Diagn"},{"key":"B14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s11306-017-1194-y","article-title":"Non-invasive urinary metabolomic profiling discriminates prostate cancer from benign prostatic hyperplasia","volume":"13","author":"P\u00e9rez-Rambla","year":"2017","journal-title":"Metabolomics"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.05.004","article-title":"Biomarker discovery in human prostate cancer: an update in metabolomics studies","volume":"9","author":"Lima","year":"2016","journal-title":"Transl Oncol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0125560","DOI":"10.1371\/journal.pone.0125560","article-title":"A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia","volume":"10","author":"Basu","year":"2015","journal-title":"PloS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1038\/s41598-018-23177-w","article-title":"Metabolomic prediction of human prostate cancer aggressiveness: magnetic resonance spectroscopy of histologically benign tissue","volume":"8","author":"Vandergrift","year":"2018","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1223527","article-title":"Significant dysregulation of lipid metabolism in patients with papillary thyroid carcinoma after thyroidectomy","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and metabolomic characterization of COVID-19 patient sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00754","article-title":"Comprehensive metabolomics and lipidomics profiling of prostate cancer tissue reveals metabolic dysregulations associated with disease development","volume":"21","author":"Lima","year":"2022","journal-title":"J Proteome Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01697","article-title":"Potential mechanisms connecting purine metabolism and cancer therapy","volume":"9","author":"Yin","year":"2018","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1039\/c9ra05046a","article-title":"Effects of Bailing capsule on diabetic nephropathy based on UPLC-MS urine metabolomics","volume":"9","author":"Xu","year":"2019","journal-title":"RSC Adv"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1160965","article-title":"LC-MS based urine untargeted metabolomic analyses to identify and subdivide urothelial cancer","volume":"13","author":"Yang","year":"2023","journal-title":"Front Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00663","article-title":"Urine metabolomics for renal cell carcinoma (RCC) prediction: tryptophan metabolism as an important pathway in RCC","volume":"9","author":"Liu","year":"2019","journal-title":"Front Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v19i8.9622","article-title":"Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study","volume":"19","author":"Akbari","year":"2021","journal-title":"Int J Reprod BioMed"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16775","article-title":"Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.777160","article-title":"Carbon ion radiotherapy evokes a metabolic reprogramming and individualized response in prostate cancer","volume":"9","author":"Ning","year":"2021","journal-title":"Front Public Health"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.959311","article-title":"Changes in aging-induced kidney dysfunction in mice based on a metabolomics analysis","volume":"13","author":"Jiao","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2018.01.055","article-title":"Targeted metabolomics in bladder cancer: From analytical methods development and validation towards application to clinical samples","volume":"1037","author":"Yumba Mpanga","year":"2018","journal-title":"Anal Chim Acta"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4793465","article-title":"Response detection of castrate-resistant prostate cancer to clinically utilized and novel treatments by monitoring phospholipid metabolism","volume":"2017","author":"Smith","year":"2017","journal-title":"BioMed Res Int"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.12.002","article-title":"Deep androgen receptor suppression in prostate cancer exploits sexually dimorphic renal expression for systemic glucocorticoid exposure","volume":"31","author":"Alyamani","year":"2020","journal-title":"Ann Oncol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jchromb.2013.09.022","article-title":"Androgen glucuronides analysis by liquid chromatography tandem-mass spectrometry: could it raise new perspectives in the diagnostic field of hormone-dependent Malignancies","volume":"940","author":"Kalogera","year":"2013","journal-title":"J Chromatogr B Analyt Technol BioMed Life Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e220228","DOI":"10.1530\/etj-22-0228","article-title":"The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications","volume":"12","author":"Torabinejad","year":"2023","journal-title":"Eur Thyroid J"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.12.009","article-title":"Clostridium scindens metabolites trigger prostate cancer progression through androgen receptor signaling","volume":"56","author":"Bui","year":"2023","journal-title":"J Microbiol Immunol Infect"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.580617","article-title":"Androgen receptor signaling and metabolic and cellular plasticity during progression to castration resistant prostate cancer","volume":"10","author":"Uo","year":"2020","journal-title":"Front Oncol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32218","article-title":"Prospective serum metabolomic profiling of lethal prostate cancer","volume":"145","author":"Huang","year":"2019","journal-title":"Int J Cancer"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1084453","article-title":"Identifying therapeutic biomarkers of zoledronic acid by metabolomics","volume":"14","author":"Li","year":"2023","journal-title":"Front Pharmacol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s13023-024-03230-w","article-title":"Plasma metabolomics signatures of developmental dysplasia of the hip in Tibet plateau","volume":"19","author":"Guo","year":"2024","journal-title":"Orphanet J Rare Dis"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2019.13.6.480","article-title":"Study of the cartilage matrix production-promoting effect of chicken leg extract and identification of the active ingredient","volume":"13","author":"Yamada","year":"2019","journal-title":"Nutr Res Pract"},{"key":"B40","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0009-8981(84)90137-2","article-title":"Analysis of dipeptides in urine by gas chromatography\/mass spectrometry: implications for collagen breakdown in iminodipeptiduria following a study of the dipeptides by electron impact and chemical ionization","volume":"138","author":"Charpentier","year":"1984","journal-title":"Clin Chim Acta"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1604169\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T05:25:39Z","timestamp":1750829139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1604169\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":40,"alternative-id":["10.3389\/fonc.2025.1604169"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1604169","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"article-number":"1604169"}}