{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:15:58Z","timestamp":1791530158377,"version":"4.3.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We present the case of a 67-year-old female who developed simultaneous metastases to the ampulla of Vater and the breast. Her medical history is significant for a radical nephrectomy performed twenty-one years prior for renal cell carcinoma (RCC). The patient was referred for evaluation due to the development of progressive jaundice, fatigue, and weight loss. A computed tomography (CT) scan of the abdomen revealed a 40 mm nodule located at the ampulla of Vater, accompanied by dilatation of the bile duct, indicative of obstructive jaundice. Additionally, ultrasonography identified a mass approximately 20 mm in size in the lateral portion of the left breast. The patient underwent a pancreatoduodenectomy to address the ampullary mass and a lumpectomy for the breast lesion. Histological examination of the resected specimens confirmed the diagnosis of metastases from RCC in both the ampulla of Vater and the breast.<\/jats:p>","DOI":"10.3389\/fonc.2025.1604170","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T05:35:57Z","timestamp":1755668157000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Late simultaneous metastasis of renal clear cell carcinoma to the ampulla and 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