{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:34Z","timestamp":1753892074338,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tumor-to-tumor metastasis (TTM) is a rare occurrence in patients with two separate primary tumors, with the more malignant tumor more commonly metastasizing to a separate primary benign or low-grade tumor. Lung carcinomas are the most common metastatic tumor donors. However, the opposite phenomenon (lung carcinoma as a recipient of metastasis from prostate adenocarcinoma) is rarely previously reported in the literature. We report the case of TTM from prostate cancer to coexisting primary lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>The 69-year-old male patient underwent surgery for tongue cancer on March 16, 2024, during which a lung mass was discovered in the right lower lung. The lung mass increased in size by follow-up thoracic computed tomography scan on October 4, 2024. Subsequently, the patient underwent single-port thoracoscopic right lower lung lobectomy and mediastinal lymph node dissection. Postoperative pathological results revealed that the lung mass had two components: lung squamous cell carcinoma and prostate cell carcinoma. MRI evaluation and PSA tests confirmed a prostate mass on November 8, 2024. Further, ultrasound-guided transperineal prostate biopsy was performed, and the biopsy pathology indicated prostate acinar adenocarcinoma. Subsequently, the patient underwent robot-assisted laparoscopic prostatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case report presents a rare and intriguing instance of TTM, specifically describing prostate adenocarcinoma metastasizing to a primary lung squamous cell carcinoma. The manuscript contributes valuable documentation to the limited literature on this rare phenomenon and is of potential interest to the oncology community.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1605846","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:25:26Z","timestamp":1749446726000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Tumor-to-tumor metastasis: a rare case of prostate adenocarcinoma metastasis to lung squamous cell carcinoma in a patient with multiple primary 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