{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:07:58Z","timestamp":1755216478800,"version":"3.43.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Retinal metastasis is an exceedingly rare manifestation of systemic cancer, accounting for less than 1% of ocular metastases. Lung adenocarcinoma is among the primary tumors that can metastasize to the retina, though such cases are seldom reported. We present a 70-year-old male with a history of lung adenocarcinoma who presented with a decline in vision in his left eye. Fundus examination revealed a large yellow-white lesion with hemorrhage in the macula and temporal retina. Multimodal imaging, including optical coherence tomography (OCT) and fluorescein angiography (FA), confirmed the diagnosis of retinal metastasis. This case underscores the importance of considering retinal metastasis in cancer patients with visual disturbances. Early diagnosis through comprehensive ophthalmic evaluation is crucial to avoid misdiagnosis.<\/jats:p>","DOI":"10.3389\/fonc.2025.1616331","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T11:19:43Z","timestamp":1754306383000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal metastasis from lung adenocarcinoma: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Danfeng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000988","article-title":"Posterior segment manifestations of ocular metastasis","volume":"34","author":"Kongwattananon","year":"2023","journal-title":"Curr Opin Ophthalmol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.003","article-title":"Metastasis","volume":"186","author":"Gerstberger","year":"2023","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13206037","article-title":"Insights into retinal metastasis from systemic carcinoma: A systematic review of clinical and multimodal imaging characteristics","volume":"13","author":"Wang","year":"2024","journal-title":"J Clin Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6615284","article-title":"Presumed retinal metastasis from lung adenocarcinoma: A case report and literature review","volume":"2021","author":"\u00d6zcan","year":"2021","journal-title":"Case Rep Ophthalmol Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003459","article-title":"Clinical features of retinal metastases: new cases integrated in a systematic review of the literature","volume":"42","author":"Gascon","year":"2022","journal-title":"Retina (Philadelphia Pa)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/23247096241272030","article-title":"Clinical case review of bilateral retinal metastasis","volume":"12","author":"Nigam","year":"2024","journal-title":"J Investig Med High Impact Case Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-022-02015-4","article-title":"Metastatic tumors to the eye. Review of metastasis to the iris, ciliary body, choroid, retina, optic disc, vitreous, and\/or lens capsule","volume":"37","author":"Shields","year":"2023","journal-title":"Eye (London England)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-024-06524-8","article-title":"Retinal metastasis from systemic carcinoma: clinical, multimodal imaging, and pathological characteristics from a multicenter case series","volume":"262","author":"Chen","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.2406","article-title":"Retinal metastasis from systemic cancer in 8 cases","volume":"132","author":"Shields","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e70170","DOI":"10.1002\/rcr2.70170","article-title":"Lung adenocarcinoma with extensive vascular invasion and retinal metastasis: A case report","volume":"13","author":"Alhariri","year":"2025","journal-title":"Respirol Case Rep"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1616331\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T11:19:43Z","timestamp":1754306383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1616331\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":10,"alternative-id":["10.3389\/fonc.2025.1616331"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1616331","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"article-number":"1616331"}}