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Based on clinical, imaging, and pathological findings, the patient was diagnosed with primary adenocarcinoma and SCC in the same lobe of the right lung, with adenocarcinoma metastasis to the lymph nodes. Few reports have described the synchronous occurrence of adenocarcinoma and SCC in the same lobe. Thoracoscopic resection of the lower lobes of the right lung and mediastinal lymph node dissection were performed. Surgical resection and postoperative chemotherapy have superior effects. The misdiagnosis of this tumor as other types of tumor must be prevented. Immunohistochemical features can be useful for the diagnosis of primary adenocarcinoma and SCC.<\/jats:p>","DOI":"10.3389\/fonc.2025.1618619","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:25:48Z","timestamp":1752729948000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenocarcinoma and squamous cell carcinoma in the same lobe of the lung with adenocarcinoma metastasis in the lymph nodes: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Chun-Sen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Xuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Dong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai-Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3614","article-title":"Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: A systematic review and meta-analysis of current evidence","volume":"10","author":"Tie","year":"2021","journal-title":"Cancer Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.09.10","article-title":"Synchronous multiple lung cancers presenting as multifocal pure ground glass nodules: are whole-body positron emission tomography\/computed tomography and brain enhanced magnetic resonance imaging necessary","volume":"8","author":"Li","year":"2019","journal-title":"Transl Lung Cancer Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)38787-2","article-title":"Diagnosis and management of synchronous lung cancers","volume":"89","author":"Ferguson","year":"1985","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1402297","article-title":"Primary squamous cell carcinoma and adenocarcinoma simultaneously occurring in the same lung lobe: A case report and literature review","volume":"14","author":"Zhang","year":"2024","journal-title":"Front Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/68631","article-title":"Multiple primary lung cancer: A literature review","volume":"27","author":"Romaszko","year":"2018","journal-title":"Adv Clin Exp medicine: Off Organ Wroclaw Med Univ"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/srep23252","article-title":"Surgical outcomes of synchronous multiple primary non-small cell lung cancers","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.11.025","article-title":"Surgical treatment of synchronous multiple lung cancer located in a different lobe or lung: high survival in node-negative subgroup","volume":"37","author":"Voltolini","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34994","article-title":"Multiple primary lung cancer: updates and perspectives","volume":"155","author":"Wang","year":"2024","journal-title":"Int J Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)40289-4","article-title":"Multiple primary lung cancers","volume":"70","author":"Martini","year":"1975","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"290s","DOI":"10.1378\/chest.07-1382","article-title":"Special treatment issues in lung cancer: accp evidence-based clinical practice guidelines (2nd edition)","volume":"132","author":"Shen","year":"2007","journal-title":"Chest"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.01.024","article-title":"The iaslc lung cancer staging project: summary of proposals for revisions of the classification of lung cancers with multiple pulmonary sites of involvement in the forthcoming eighth edition of the tnm classification","volume":"11","author":"Detterbeck","year":"2016","journal-title":"J Thorac oncology: Off Publ Int Assoc Study Lung Cancer"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000195933","article-title":"Adenocarcinoma and squamous cell carcinoma in the same lobe of the lung. 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