{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:19:18Z","timestamp":1763356758809,"version":"3.45.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benign Fibrous Histiocytoma (BFH), also known as dermatofibroma, is a common benign mesenchymal tumor of the skin. Although typically non-aggressive, rare cases of metastatic BFH pose diagnostic and therapeutic challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study reviews 10 cases of metastatic BFH diagnosed at Fudan University Shanghai Cancer Center between 2009 and 2024, with a detailed examination of three cases involving recurrent and metastatic behavior. Immunohistochemical markers and radiological imaging findings were analyzed to characterize tumor progression and treatment responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cases highlighted distinct patterns of recurrence and metastasis, including lymphatic and distant organ involvement. Immunohistochemical analysis demonstrated variable expression of markers such as Vimentin, CD68, CD163, Ki67, and SMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Metastatic BFH remains a rare but clinically significant condition. Early recognition, accurate histopathological diagnosis, and multimodal therapies are crucial for effective management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1621760","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:16:33Z","timestamp":1763356593000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Metastatic benign fibrous histiocytoma: a case series and review of diagnostic and therapeutic challenge"],"prefix":"10.3389","volume":"15","author":[{"given":"Xuesi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingrong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangbai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangjun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027001036.x","article-title":"Dermatofibroma is a clonal proliferative disease","volume":"27","author":"Chen","year":"2000","journal-title":"J Cutaneous Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14574","article-title":"Recurrent and metastatic cellular cutaneous fibrous histiocytoma: A case report and literature review","volume":"51","author":"Fuentes-S\u00e1nchez","year":"2024","journal-title":"J Cutaneous Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(82)80019-8","article-title":"Benign fibrous histiocytoma of the skin. 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