{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:34:20Z","timestamp":1791995660626,"version":"4.4.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reliable prediction of long-term survival in colon cancer remains limited by staging system constraints. CEA and tumor deposits (TD) are known prognostic markers, but their combined predictive value is underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 1, 029 patients with locally advanced colon cancer who underwent radical resection. A CEA-TD scoring system was developed and integrated with key clinicopathologic variables to construct a prognostic nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both TD(+) and elevated CEA levels were independently associated with significantly worse overall survival (HR for TD\u00a0=\u00a01.985, CEA\u00a0=\u00a02.209; all P &amp;lt; 0.01). The CEA-TD score effectively stratified patients into four risk categories, each with distinct survival outcomes (P &amp;lt; 0.001). The final nomogram, incorporating CEA-TD score, T stage, N stage, grade, and tumor location, demonstrated high\u00a0predictive performance, with AUCs of 0.796, 0.834, and 0.807 for 1-, 3-, and 5-year OS in the training cohort, and comparable values in internal and external validations. The C-index reached 0.800, outperforming traditional prognostic factors. Kaplan-Meier and risk curve analyses confirmed the model\u2019s discriminative capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CEA-TD-based nomogram offers accurate, clinically applicable risk stratification for LOCC patients, supporting personalized treatment strategies and improved prognostic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1626538","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:59:45Z","timestamp":1765961985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A large-scale study integrating CEA and tumor deposits to evaluate prognosis in colon cancer 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