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This case report describes a 54-year-old male patient who presented with a rectal cancer metastatic mass accompanied by erosion in the left gluteal area, diagnosed as poorly differentiated adenocarcinoma, along with significant cachexia and pelvic and lymph node metastases. Despite undergoing CAPEOX chemotherapy, no notable tumor shrinkage was observed. In light of this, a multidisciplinary consultation led to the adoption of an innovative approach that included transiliac artery chemotherapy embolization and the implantation of an arterial chemotherapy pump for mFOLFOX6 combined with bevacizumab. Following four cycles of reduced-dose arterial infusion chemotherapy, the tumor in the gluteal region demonstrated a remarkable reduction of approximately 90%. This case showcases a promising treatment modality that integrates localized arterial embolization and chemotherapy, along with supportive care. The approach significantly improved the patient\u2019s quality of life and extended survival in individuals facing advanced colorectal cancer with gluteal muscle metastasis, suggesting that this therapy merits further investigation and potential implementation in clinical practice.<\/jats:p>","DOI":"10.3389\/fonc.2025.1630104","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T05:34:14Z","timestamp":1756791254000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["An innovative treatment approach using iliac artery embolization and implanted port for chemotherapy in a patient with gluteal muscle metastasis of advanced colon cancer: a case report and literature 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