{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:47:15Z","timestamp":1767764835903,"version":"3.48.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the management of a rare chest wall solitary fibrous tumor (SFT) complicated by Doege\u2013Potter syndrome (DPS), emphasizing the critical roles of multidisciplinary consultation and preoperative vascular embolization in optimizing outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 56-year-old male presented with exertional dyspnea, dizziness, recurrent hypoglycemia, and hypokalemia. Contrast-enhanced computed tomography (CT) identified a large chest wall mass (19.2 \u00d7 13.3 \u00d7 21.6 cm), with biopsy confirming SFT. Multidisciplinary evaluation established a diagnosis of DPS. The patient underwent three cycles of neoadjuvant chemo-immunotherapy (albumin-bound paclitaxel, cisplatin, and anlotinib), followed by preoperative tumor vascular embolization. Surgical intervention involved en bloc tumor resection, left upper lobe wedge resection, and partial resection of the fifth rib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neoadjuvant therapy resulted in stable disease per RECIST 1.1 criteria. Preoperative embolization significantly reduced intraoperative blood loss to 200 mL, enabling an uneventful surgery. Postoperatively, hypoglycemia and hypokalemia resolved, and lung re-expansion was satisfactory. As of December 31, 2024, outpatient follow-up revealed no evidence of recurrence or metabolic abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the importance of recognizing DPS as a rare manifestation of chest wall SFT and underscores the value of multidisciplinary strategies in managing large tumors. Preoperative vascular embolization effectively minimized surgical risks and corrected metabolic disturbances, facilitating successful resection. Further studies are warranted to refine therapeutic approaches for this uncommon clinical entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1630793","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:14:46Z","timestamp":1767762886000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Solitary fibrous tumor of the chest wall with Doege\u2013Potter syndrome: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Hongfei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fasheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers15164166","article-title":"Surgery for solitary fibrous tumors of the pleura: A review of the available evidence","volume":"15","author":"Bertoglio","year":"2023","journal-title":"Cancers"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2174\/1871530323666230623112047","article-title":"Doege-potter syndrome; A case of solitary fibrous pleura tumor associated with severe hypoglycemia: A case report in internal medicine","volume":"23","author":"Castaldo","year":"2023","journal-title":"Endocrine Metab Immune Disord Drug Targets"},{"key":"B3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1749-8090-4-45","article-title":"Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrome","volume":"4","author":"Kalebi","year":"2009","journal-title":"J Cardiothoracic Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw221","article-title":"Doege-Potter syndrome: hypoglycaemic coma in a 90-year old due to a solitary fibrous tumour","volume":"46","author":"Avramenko","year":"2017","journal-title":"Age Ageing"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e7417","DOI":"10.1097\/MD.0000000000007417","article-title":"Doege-Potter syndrome: A review of the literature including a new case report","volume":"96","author":"Han","year":"2017","journal-title":"Medicine"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K08E-062","article-title":"Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia","volume":"55","author":"Tani","year":"2008","journal-title":"Endocrine J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.08.022","article-title":"Hypoglycemia and finger clubbing-consider Doege-Potter","volume":"126","author":"Fritzsche","year":"2013","journal-title":"Am J Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2015.78.2.120","article-title":"A case of solitary fibrous pleura tumor associated with severe hypoglycemia: doege-potter syndrome","volume":"78","author":"Jang","year":"2015","journal-title":"Tuberculosis Respir Dis"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2015.0023","article-title":"Doege-potter syndrome","volume":"97","author":"Ahluwalia","year":"2015","journal-title":"Ann R Coll Surgeons England"},{"key":"B10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ctrv.2015.11.007","article-title":"The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: A systematic review of the literature","volume":"42","author":"Pillay","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"B11","doi-asserted-by":"publisher","first-page":"c951","DOI":"10.1136\/bmj.c951","article-title":"Multidisciplinary team working in cancer: what is the evidence","volume":"340","author":"Taylor","year":"2010","journal-title":"BMJ (Clin Res ed)"},{"key":"B12","article-title":"Impact of a multidisciplinary thoracic oncology clinic on the timeliness of care","volume":"1","author":"Riedel","year":"2006","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14041064","article-title":"Novel therapeutic options for solitary fibrous tumor: antiangiogenic therapy and beyond","volume":"14","author":"de Bernardi","year":"2022","journal-title":"Cancers"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.081","article-title":"Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis","volume":"23","author":"Hicklin","year":"2005","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040370","article-title":"The vascular endothelial growth factor (VEGF)\/VEGF receptor system and its role under physiological and pathological conditions","volume":"109","author":"Takahashi","year":"2005","journal-title":"Clin Sci (London England: 1979)"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32833aaad4","article-title":"Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma\/solitary fibrous tumor","volume":"22","author":"Park","year":"2010","journal-title":"Curr Opin Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.t01-1-01423.x","article-title":"Immunohistochemical localization of endothelial cell markers in solitary fibrous tumor","volume":"52","author":"Sawada","year":"2002","journal-title":"Pathol Int"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/path.1195","article-title":"Steroid hormone receptor in pleural solitary fibrous tumours and CD34+ progenitor stromal cells","volume":"198","author":"Bongiovanni","year":"2002","journal-title":"J Pathol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1007\/s12672-024-01492-1","article-title":"The efficacy and safety of anlotinib combined with chemotherapy in treatment of advanced soft tissue sarcoma","volume":"15","author":"Ni","year":"2024","journal-title":"Discov Oncol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3766","article-title":"Safety and efficacy of anlotinib, a multikinase angiogenesis inhibitor, in patients with refractory metastatic soft-tissue sarcoma","volume":"24","author":"Chi","year":"2018","journal-title":"Clin Cancer Res:  Off J Am Assoc Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e30173","DOI":"10.7759\/cureus.30173","article-title":"Preoperative embolization of a giant solitary fibrous tumor of the pleura: A case report","volume":"14","author":"Lopera Valle","year":"2022","journal-title":"Cureus"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2012.120339","article-title":"Interventional embolization of giant thoracic tumors before surgical resection","volume":"54","author":"Liu","year":"2013","journal-title":"Acta Radiol (Stockholm Sweden: 1987)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03117-4","article-title":"Preoperative embolization of a massive solitary fibrous tumor of the pleura","volume":"73","author":"Weiss","year":"2002","journal-title":"Ann Thorac Surg"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1630793\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:14:50Z","timestamp":1767762890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1630793\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":23,"alternative-id":["10.3389\/fonc.2025.1630793"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1630793","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"article-number":"1630793"}}