{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:13:24Z","timestamp":1792491204231,"version":"4.5.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Solid papillary carcinoma (SPC) of the breast is considered a special subtype of ductal carcinoma <jats:italic>in situ<\/jats:italic> (DCIS), characterized by distinctive histological features and growth patterns. Although SPC itself is not very common, it is particularly noteworthy that distant metastasis from its non-invasive form is highly uncommon. This contrasts sharply with infiltrative solid papillary carcinoma (ISPC), which lacks the typical myoepithelial cell layer seen in SPC and displays a map-like infiltrative growth pattern, often involving adipose and fibrous stromal infiltration. This study reports a case of a patient who was diagnosed with <jats:italic>in situ<\/jats:italic> SPC following a total mastectomy, and subsequently developed pulmonary metastatic ISPC five years later. The case supports the concept of a morphological continuum from <jats:italic>in situ<\/jats:italic> SPC to invasive carcinoma and highlights that even non-invasive SPC may possess the distant metastasis, albeit rarely. These findings provide new insights into the biological behavior of this rare breast cancer subtype.<\/jats:p>","DOI":"10.3389\/fonc.2025.1630957","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:17:17Z","timestamp":1759897037000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metastasis of in situ solid papillary carcinoma of the breast to the lungs:a rare case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Jing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0047-1","article-title":"Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or Malignant papillary lesions of the breast: a comparative study of 9 additional cases","volume":"31","author":"Alsadoun","year":"2018","journal-title":"Mod Pathol"},{"key":"B2","first-page":"5","article-title":"Solid papillary carcinoma (insitu and invasive)","volume-title":"WHO classification of tumors editorial board","author":"Mac Grogan","year":"2019"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-179","article-title":"Breast ductal carcinoma in situ presenting as recurrent non-puerperal mastitis: case report and literature review","volume":"11","author":"Liong","year":"2013","journal-title":"World J Surg Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000702","article-title":"Clinicopathologic characteristics of solid papillary carcinoma of the breast","volume":"40","author":"Tan","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"B5","article-title":"Solid papillary carcinoma of the nipple: an in situ carcinoma or an expansive growth tumor","volume":"108","author":"Tacchini","year":"2016","journal-title":"Pathologica"},{"key":"B6","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12905-023-02596-6","article-title":"Infiltrative solid papillary carcinoma of the breast with axillary lymph node metastasis: a case report","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Womens Health"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00732-3","article-title":"Papillary neoplasms of the breast-reviewing the spectrum","volume":"34","author":"Tay","year":"2021","journal-title":"Mod Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0227-RS","article-title":"Solid papillary carcinoma of the breast: a pathologically and clinically distinct breast tumor","volume":"136","author":"Saremian","year":"2012","journal-title":"Arch Pathol Lab Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199511000-00003","article-title":"Solid papillary carcinoma of the breast. 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