{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:45:44Z","timestamp":1781322344850,"version":"3.54.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Primary cardiac lymphoma (PCL) is an extremely rare and highly aggressive malignancy that typically presents with nonspecific cardiac symptoms. We report a case of primary cardiac diffuse large B-cell lymphoma (DLBCL) with initial manifestations of heart failure and third-degree atrioventricular block. The patient presented with progressive dyspnea, palpitations, and unintentional weight loss. Transthoracic echocardiography revealed a large right atrial mass. The patient first underwent surgical resection of the cardiac tumor, and pathological examination confirmed non-GCB subtype DLBCL. During fractionated R-CHOP chemotherapy, the patient experienced cardiac arrest, necessitating the urgent implantation of a temporary pacemaker. Subsequently, a permanent pacemaker was implanted using a physiological pacing strategy. After six cycles of chemotherapy and ongoing pacing support, the patient achieved complete remission, with no evidence of tumor recurrence during the follow-up period. This case suggests that for PCL patients presenting with heart failure and third-degree atrioventricular block, a combination of surgical resection, fractionated R-CHOP chemotherapy, and physiological pacing may contribute to a favorable outcome.<\/jats:p>","DOI":"10.3389\/fonc.2025.1635860","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T04:14:25Z","timestamp":1761279265000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary cardiac lymphoma presenting as heart failure and atrioventricular block: case 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