{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:33:06Z","timestamp":1769880786408,"version":"3.49.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Epstein\u2013Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare tumor that typically arises in the liver or spleen and is characterized by spindle-shaped cells within a dense lymphoplasmacytic background. We report a case of a 64-year-old woman with an incidental splenic mass found during routine imaging. MRI showed a 4.8 cm lesion with progressive enhancement. The patient underwent laparoscopic partial splenectomy. Histopathological examination revealed features consistent with EBV+ IFDCS, including positivity for CD21, CD23, CD35, SMA, EMA, and EBER. EBV+ IFDCS often presents with nonspecific symptoms and imaging findings, making diagnosis challenging. Definitive diagnosis relies on histology, immunohistochemistry, and confirmation of EBV infection. Most cases follow an indolent clinical course and have a favorable prognosis after complete surgical resection, though rare aggressive cases have been reported. Understanding its clinicopathological and molecular features is essential for accurate diagnosis and management.<\/jats:p>","DOI":"10.3389\/fonc.2025.1640099","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:31:03Z","timestamp":1755858663000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Yi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juner","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yewu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuchan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/(SICI)1097-0142(19970115)79:2<294::AID-CNCR13>3.0.CO;2-W","article-title":"Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a Malignant potential higher than currently recognized","volume":"79","author":"Chan","year":"1997","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14169","article-title":"Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma presenting as a solitary colonic mass: two rare cases and a literature review","volume":"77","author":"Ke","year":"2020","journal-title":"Histopathology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002011","article-title":"Challenges in the diagnosis of epstein-barr virus-positive inflammatory follicular dendritic cell sarcoma: extremely wide morphologic spectrum and immunophenotype","volume":"47","author":"Li","year":"2023","journal-title":"Am J Surg Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-331","article-title":"Follicular dendritic cell sarcoma","volume":"113","author":"Facchetti","year":"2021","journal-title":"Pathologica"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001632","article-title":"New clinicopathologic scenarios of EBV+ Inflammatory follicular dendritic cell sarcoma: report of 9 extrahepatosplenic cases","volume":"45","author":"Jiang","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1017\/S0950268816002405","article-title":"Overwhelming post-splenectomy sepsis in patients with asplenia and hyposplenia: a retrospective cohort study","volume":"145","author":"Chong","year":"2017","journal-title":"Epidemiol Infect"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7002","article-title":"Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension","volume":"97","author":"Kinjo","year":"2010","journal-title":"Br J Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-24-483","article-title":"A case report: spleen Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma","volume":"15","author":"Chen","year":"2024","journal-title":"J Gastrointestinal Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13000-024-01457-6","article-title":"Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma with significant granuloma: case report and literature review","volume":"19","author":"Nie","year":"2024","journal-title":"Diagn Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e32997","DOI":"10.1016\/j.heliyon.2024.e32997","article-title":"Epstein-barr virus (EBV)-positive inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) presenting as thrombocytopenia: A case report and literature review","volume":"10","author":"Jin","year":"2024","journal-title":"Heliyon"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e32528","DOI":"10.1097\/MD.0000000000032528","article-title":"Inflammatory pseudotumor-like follicular dendritic cell sarcoma with first clinical manifestation of thrombocytopenia: A case report","volume":"101","author":"Leng","year":"2022","journal-title":"Medicine"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231168345","article-title":"EBV-positive inflammatory follicular dendritic cell sarcoma of the spleen: report of an aggressive form with molecular characterization","volume":"32","author":"Baber","year":"2024","journal-title":"Int J Surg Pathol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3233\/THC-248038","article-title":"Imaging findings of Epstein-Barr Virus-positive inflammatory follicular dendritic cell sarcoma of spleen: A case report","volume":"32","author":"Zhao","year":"2024","journal-title":"Technol Health Care: Off J Eur Soc Eng Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"rjac034","DOI":"10.1093\/jscr\/rjac034","article-title":"Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma","volume":"5","author":"Ungureanu","year":"2022","journal-title":"J Surg Case Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"rjae600","DOI":"10.1093\/jscr\/rjae600","article-title":"A rare case of an EBV-positive inflammatory follicular dendritic cell tumor of the spleen","volume":"9","author":"Eid","year":"2024","journal-title":"J Surg Case Rep"},{"key":"B16","article-title":"Inflammatory pseudotumor-like follicular dendritic cell sarcoma: a rare presentation of a hepatic mass","volume":"12","author":"Deng","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s40792-022-01572-w","article-title":"Epstein-Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature","volume":"8","author":"Abe","year":"2022","journal-title":"Surg Case Rep"},{"key":"B18","article-title":"Clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma","volume":"7","author":"Ge","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12057","article-title":"Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells","volume":"63","author":"Choe","year":"2013","journal-title":"Pathol Int"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59071341","article-title":"Epstein-barr virus-positive inflammatory follicular dendritic cell sarcoma presenting as a colonic polyp: report of a case with a literature review","volume":"59","author":"Hu","year":"2023","journal-title":"Med (Kaunas Lithuania)"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-024-04461-y","article-title":"Stroma-derived neoplasms and pseudoneoplastic lesions of the spleen: a select review of pathologic and CT\/MRI findings","volume":"50","author":"Prasad","year":"2025","journal-title":"Abdominal Radiol (New York)"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4021\/gr2010.05.206w","article-title":"Follicular dendritic cell tumor in liver: A case report and collective review","volume":"3","author":"Lee","year":"2010","journal-title":"Gastroenterol Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13182916","article-title":"Aggressive variant of hepatic epstein-barr virus-associated inflammatory pseudotumor-like follicular dendritic cell sarcoma with PD-L1 and SSTR2a expression","volume":"13","author":"Pardasani","year":"2023","journal-title":"Diagnostics (Basel Switzerland)"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2016.05.003","article-title":"Follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of MDM2, somatostatin receptor 2A, and PD-L1","volume":"23","author":"Agaimy","year":"2016","journal-title":"Ann Diagn Pathol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"141600","DOI":"10.1016\/j.ijbiomac.2025.141600","article-title":"BSRF1 modulates IFN-\u03b2-mediated antiviral responses by inhibiting NF-\u03baB activity via an IKK-dependent mechanism in Epstein-Barr virus infection","volume":"306","author":"Chen","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-022-00715-3","article-title":"Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy","volume":"45","author":"Patrad","year":"2022","journal-title":"Cell Oncol (Dordrecht Netherlands)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1266897","article-title":"Case Report: Identification of a novel STAT3 mutation in EBV-positive inflammatory follicular dendritic cell sarcoma","volume":"13","author":"Ramsey","year":"2023","journal-title":"Front Oncol"},{"key":"B28","article-title":"Follicular dendritic cell tumor: review of the entity","volume":"15","author":"Perez-Ordo\u00f1ez","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2024.09.27","article-title":"Uncommon granulomatous manifestation in Epstein-Barr virus-positive follicular dendritic cell sarcoma: a case report","volume":"59","author":"Shen","year":"2025","journal-title":"J Pathol Trans Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1640099\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:31:04Z","timestamp":1755858664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1640099\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":29,"alternative-id":["10.3389\/fonc.2025.1640099"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1640099","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"article-number":"1640099"}}