{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:06:06Z","timestamp":1785855966777,"version":"3.56.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>A 68-year-old man came to evaluate a gastric polyp discovered during a routine gastroscopy. After endoscopic mucosal resection, pathological findings confirmed that it\u2019s a hyperplastic polyp. Notably, squamous metaplasia was observed within the hyperplastic polyp, and both squamous and glandular epithelium exhibited high-grade intraepithelial neoplasia. Besides, the diagnosis of autoimmune gastritis was established by comprehensive assessment including gastric endoscopic findings, histopathological examination and serological studies. The patient experienced no postoperative discomfort and had oral medication for two weeks. In this paper, we presents a first case worldwide of hyperplastic polyp with synchronous high-grade intraepithelial neoplasia in both glandular and squamous epithelium in autoimmune gastritist. In previous cases, the occurrence of hyperplastic polyps with neoplastic transformations or squamous metaplasia is very rare, but what we found this time was the concurrance of both lesions on hyperplastic polyps. This extremely rare case not only provides further clinical evidence for the metaplasia and neoplastic transformation potential of hyperplastic polyps, but also highlights the necessity of regular follow-up examination for autoimmune gastritis - a well-established precancerous condition.<\/jats:p>","DOI":"10.3389\/fonc.2025.1641188","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:10:25Z","timestamp":1755231025000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: A rare hyperplastic polyp with synchronous high-grade intraepithelial neoplasia in both glandular and squamous epithelium in autoimmune gastritis"],"prefix":"10.3389","volume":"15","author":[{"given":"Dian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Hendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i42.5781","article-title":"Research status and hotspots of autoimmune gastritis: A bibliometric analysis","volume":"29","author":"Yu","year":"2023","journal-title":"World J Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i42.12179","article-title":"Rugge M.Autoimmune gastritis: Pathologist\u2019s viewpoint","volume":"21","author":"Coati","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01954-9","article-title":"Diagnostic criteria and endoscopic and histological findings of autoimmune gastritis in Japan","volume":"58","author":"Kamada","year":"2023","journal-title":"J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.4251\/wjgo.v14.i2.396","article-title":"Gastric epithelial histology and precancerous conditions","volume":"14","author":"Yang","year":"2022","journal-title":"World J Gastrointest Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i40.8883","article-title":"Pathophysiological and clinical aspects of gastric hyperplastic polyps","volume":"22","author":"Markowski","year":"2016","journal-title":"World J Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31828d185d","article-title":"Neuroendocrine proliferations of the stomach: a pragmatic approach for the perplexed pathologist","volume":"20","author":"Cockburn","year":"2013","journal-title":"Adv Anat Pathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1053\/j.gastro.2021.06.078","article-title":"AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review","volume":"161","author":"Shah","year":"2021","journal-title":"Gastroenterology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2016.59474","article-title":"Gastric hyperplastic polyps coexisting with early gastric cancers, adenoma and neuroendocrine cell hyperplasia","volume":"67","author":"Karpi\u0144ska-Kaczmarczyk","year":"2016","journal-title":"Pol J Pathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1055\/A-1117-3166","article-title":"Risk of neoplastic change in large gastric hyperplastic polyps and recurrence after endoscopic resection","volume":"52","author":"Fort\u00e9","year":"2020","journal-title":"Endoscopy"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6548","DOI":"10.3390\/ijms22126548","article-title":"Gastritis, gastric polyps and gastric cancer","volume":"22","author":"Waldum","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1038\/s41598-020-58900-z","article-title":"Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients","volume":"10","author":"Hu","year":"2020","journal-title":"Sci Rep"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.06.001","article-title":"Evaluation and management of gastric epithelial polyps","volume":"31","author":"Castro","year":"2017","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"B13","article-title":"Warren B british society of gastroenterology","volume":"59","author":"Goddard","year":"2010","journal-title":"Manage Gastric Polyps Gut"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.1932","article-title":"Malignant transformation of hyperplastic gastric polyps: An immunohistochemical and pathological study of the changes of neoplastic phenotype","volume":"7","author":"Imura","year":"2014","journal-title":"Oncol Lett"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0572-8","article-title":"Gastric hyperplastic polyps: a review","volume":"54","author":"Jain","year":"2009","journal-title":"Dig Dis Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9556-6","article-title":"Malignant transformation of foveolar hyperplastic polyp of the stomach: a histopathological study","volume":"28","author":"Terada","year":"2011","journal-title":"Med Oncol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nrc.2017.68","article-title":"Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence","volume":"17","author":"Giroux","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02542-8","article-title":"A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach","volume":"475","author":"Yamada","year":"2019","journal-title":"Virchows Archiv"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2013.46.4.407","article-title":"A case of squamous metaplasia of the stomach","volume":"46","author":"Jeon","year":"2013","journal-title":"Clin Endosc"},{"key":"B20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13000-015-0281-5","article-title":"Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma","volume":"10","author":"Ahn","year":"2015","journal-title":"Diagn Pathol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.6271-20","article-title":"Metaplasia of the stomach associated with lymphoma infiltration","volume":"60","author":"Iwamuro","year":"2021","journal-title":"Intern Med"},{"key":"B22","article-title":"Adenoacanthoma of the pyloric end of the stomach: a consideration of its histogenesis and a report of two cases","volume":"36","author":"Wood","year":"1943","journal-title":"Arch Pathol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255807","article-title":"Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia","volume":"42","author":"Oono","year":"2010","journal-title":"Endoscopy"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1641188\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:10:36Z","timestamp":1755231036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1641188\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":23,"alternative-id":["10.3389\/fonc.2025.1641188"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1641188","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"article-number":"1641188"}}