{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:21:23Z","timestamp":1773354083401,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to explore the feasibility and safety of modified negative-pressure wound therapy with instillation (NPWTi) for the treatment of cervical anastomotic leakage (CAL) after oesophageal cancer surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 17 patients who developed CAL after oesophageal cancer surgery and received modified NPWTi treatment at our hospital from 2021 to 2024. The primary outcome was the time to healing, defined as the number of days from the initiation of modified NPWTi to complete fistula closure. Secondary outcomes included wound odour improvement and patient comfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 17 patient were collected, including 10 men and seven women, with an average age of 73.71 \u00b1 8.01 years. None received neoadjuvant therapy, and no patients had diabetes; preoperative albumin was 38.77 \u00b1 3.58 g\/L. The occurrence of CAL was noted at 8.88 \u00b1 3.15\u00a0d (95% CI: 7.26 to 10.51\u00a0d) post-surgery. The modified treatment was commenced 0\u201312 d after CAL diagnosis, with the earliest case starting on the day of diagnosis. The mean duration of modified NPWTi was 10.88 \u00b1 6.54\u00a0d (95% CI: 7.52 to 14.25\u00a0d). For the primary outcome, the time from treatment initiation to complete healing was 15.00 \u00b1 7.26\u00a0d (95% CI: 11.27 to 18.73\u00a0d), with a minimum of five days. No mediastinal or pleural infections related to NPWTi occurred during the treatment. For the secondary outcomes, a significant improvement in wound odour was observed following the administration of the modified NPWTi (P&amp;lt;0.001), with an improvement rate of 100% (95% CI: 85-100%). During the treatment, the patients reported feeling comfortable and expressed overall satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Modified NPWTi demonstrated significant efficacy and convenience in treating CAL after oesophageal cancer surgery, benefiting both patients and healthcare providers with good safety profiles, thus warranting broader clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1644593","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:16:23Z","timestamp":1764566183000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Study on the application of modified negative pressure wound therapy with instillation in cervical anastomotic leakage after oesophageal cancer surgery"],"prefix":"10.3389","volume":"15","author":[{"given":"Linrong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanli","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bomeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanjuan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doz089","article-title":"Risk factors and outcomes associated with anastomotic leaks following esophagectomy: a systematic review and meta-analysis","volume":"33","author":"Kamarajah","year":"2020","journal-title":"Dis Esophagus"},{"key":"B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000322014","article-title":"Cervical or thoracic anastomosis after esophagectomy for cancer: a systematic review and meta-analysis","volume":"28","author":"Biere","year":"2011","journal-title":"Dig Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup10.S38","article-title":"Use of cryopreserved umbilical cord with negative pressure wound therapy for complex diabetic ulcers with osteomyelitis","volume":"26","author":"Raphael","year":"2017","journal-title":"J Wound Care"},{"key":"B4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.23750\/abm.v88i3.5737","article-title":"Use of ultraportable vacuum therapy systems in the treatment of venous leg ulcer","volume":"88","author":"Cuomo","year":"2017","journal-title":"Acta BioMed"},{"key":"B5","article-title":"Developing a tool for researching fungating wounds","author":"Grocott","year":"2001","journal-title":"World wide wounds"},{"key":"B6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.5761\/atcs.oa.20-00139","article-title":"Risk factors of cervical anastomotic leakage after mcKeown minimally invasive esophagectomy: focus on preoperative and intraoperative lung function","volume":"27","author":"Gao","year":"2021","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-015-1231-2","article-title":"Effects of body mass index (BMI) on surgical outcomes: a nationwide survey using a Japanese web-based database","volume":"45","author":"Ri","year":"2015","journal-title":"Surg Today"},{"key":"B8","article-title":"Vacuum sealing as treatment of soft tissue damage in open fractures","volume":"96","author":"Fleischmann","year":"1993","journal-title":"Unfallchirurg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12132","article-title":"Negative pressure wound therapy as an adjunct in healing of chronic wounds","volume":"12","author":"Langer","year":"2015","journal-title":"Int Wound J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/1534734618794856","article-title":"Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation","volume":"17","author":"Liu","year":"2018","journal-title":"Int J Low Extrem Wounds"},{"key":"B11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jccw.2014.02.001","article-title":"Negative pressure wound therapy with instillation (NPWTi) better reduces post-debridement bioburden in chronically infected lower extremity wounds than NPWT alone","volume":"4","author":"Goss","year":"2012","journal-title":"J Am Coll Clin Wound Spec"},{"key":"B12","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1742-481X.2007.00423.x","article-title":"Negative pressure wound therapy with instillation: a pilot study describing a new method for treating infected wounds","volume":"5","author":"Gabriel","year":"2008","journal-title":"Int Wound J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13019-021-01435-9","article-title":"Application of mediastinal drainage tube in intrathoracic esophageal anastomotic leakage for early diagnosis and effective treatment: a retrospective study","volume":"16","author":"Ma","year":"2021","journal-title":"J Cardiothorac Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13017-019-0235-4","article-title":"Management of intrathoracic and cervical anastomotic leakage after esophagectomy for esophageal cancer: a systematic review","volume":"14","author":"Verstegen","year":"2019","journal-title":"World J Emerg Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-21-605","article-title":"A randomized trial of negative pressure wound therapy technology combined with intermittent instillation in the treatment of neck anastomotic leakage after esophageal cancer surgery","volume":"12","author":"Luo","year":"2021","journal-title":"J Gastrointest Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2016\/733","article-title":"A prospective randomized trial of vacuum-assisted closure versus standard therapy of chronic non-healing wounds","volume":"5","author":"Raghupathy","year":"2016","journal-title":"J Evolution Med Dent Sci"},{"key":"B17","first-page":"6s","article-title":"A literature review of negative pressure wound therapy","author":"Gupta","year":"2004","journal-title":"Wounds-A Compendium Clin Res Pract"},{"key":"B18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ajps.2018.09.001","article-title":"Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound","volume":"14","author":"Namviriyachote","year":"2019","journal-title":"Asian J Pharm Sci"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1644593\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:16:25Z","timestamp":1764566185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1644593\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":18,"alternative-id":["10.3389\/fonc.2025.1644593"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1644593","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"article-number":"1644593"}}