{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:54:43Z","timestamp":1763618083576,"version":"3.45.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Tumors are the major diseases that threaten people\u2019s health and life at present. Liver injury often happens in patients with cancer, and which mostly attribute to application of anti-cancer drugs. However, some cases caused by the infiltration and destruction of metastatic cancer, and anti-tumor drugs play a key role in restoring liver function instead of inducing drug induced liver injury (DILI). This article reports a case of tumor-associated Liver Injury (TALI) who suffered HER2-negative metastatic breast cancer with liver metastasis, but her liver function was recovery after treatment with Alpelisib, an anti-tumor drug, as meanwhile as achieving anti-tumor. Through this case we aims to emphasize to differentiate the causes of TALI and make the treatment strategies accordingly.<\/jats:p>","DOI":"10.3389\/fonc.2025.1644790","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:11:29Z","timestamp":1763615489000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of tumor-associated liver injury alleviated with antineoplastic 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