{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:42:10Z","timestamp":1760330530562,"version":"build-2065373602"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We report a case of a 34-year-old female presenting with a rapidly enlarging right breast mass. Ultrasonographic evaluation revealed a large solid mass accompanied by ipsilateral axillary lymphadenopathy. Histopathological examination of the biopsy specimen showed an unusual rowth pattern of atypical cells, characterized by perivascular \u201ctarget-like\u201d and \u201csoldier-like\u201d arrangements, which closely mimicked lobular carcinoma and posed significant challenges to the diagnostic process. Immunohistochemical (IHC) staining was crucial in differentiating this lymphoma from breast carcinoma, with positive results for LCA, CD20 and CD19, and negative for ER and PR. Following multiple rounds of IHC testing, the final diagnosis was confirmed as diffuse large B-cell lymphoma (DLBCL), non-special type (NOS). Further staging revealed no distant metastasis. The case of primary breast DLBCL highlights us a rare perivascular target-like growth pattern of tumor cells. The inclusion of LCA in the IHC panel is recommended to aid in accurate diagnosis and guide appropriate treatment, especially when histological patterns are ambiguous.<\/jats:p>","DOI":"10.3389\/fonc.2025.1646986","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:16:54Z","timestamp":1760329014000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary diffuse large B-cell lymphoma of the breast with rare growth pattern mimics lobular carcinoma: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Si","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boju","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congwei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"B1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2017"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920201)69:3<725::aid-cncr2820690320>3.0.co;2-c","article-title":"Primary non-Hodgkin\u2019s lymphomas of the female breast","volume":"69","author":"Giardini","year":"1992","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt192","article-title":"Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options","volume":"24","author":"Aviv","year":"2013","journal-title":"Ann Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5483","article-title":"Primary breast lymphoma: A single center study","volume":"13","author":"Zhang","year":"2017","journal-title":"Oncol Lett"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197206)29:6<1705::aid-cncr2820290640>3.0.co;2-i","article-title":"Primary lymphoma of the breast","volume":"29","author":"Wiseman","year":"1972","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-022-01382-w","article-title":"Patterns of treatment and their outcomes in primary breast lymphoma; a comprehensive population-based analysis","volume":"29","author":"Mustafa Ali","year":"2022","journal-title":"Breast Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e73069","DOI":"10.7759\/cureus.73069","article-title":"A rare case of diffuse large B-cell lymphoma in the breast: diagnostic insights and treatment approaches","volume":"16","author":"Kouhen","year":"2024","journal-title":"Cureus"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpra.2022.01.004","article-title":"Primary lymphomas of the breast: A review","volume":"32","author":"James","year":"2022","journal-title":"JPRAS Open"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115304","article-title":"Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma","volume":"386","author":"Tilly","year":"2022","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.110120","article-title":"Primary breast lymphoma: A rare case report","volume":"122","author":"Alkerata","year":"2024","journal-title":"Int J Surg Case Rep"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1646986\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:16:55Z","timestamp":1760329015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1646986\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":11,"alternative-id":["10.3389\/fonc.2025.1646986"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1646986","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"article-number":"1646986"}}