{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:41:22Z","timestamp":1767206482631,"version":"build-2238731810"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009620","name":"Science and Technology Department of Gansu Province","doi-asserted-by":"publisher","award":["2020-0406-JCC-0439"],"award-info":[{"award-number":["2020-0406-JCC-0439"]}],"id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Substernal goiter (SG) refers to an enlargement of the thyroid gland that extends below the sternal notch or clavicle. While most cases are benign, a few may be malignant. Surgical resection is the standard treatment for SGs that cause clinical symptoms. This case report presents a 60-year-old female SG patient with a history of thyroidectomy and congenital vascular anomalies, who developed symptoms including significant airway compression and difficulty swallowing liquids. Following a detailed imaging and pathological evaluation, ultrasound-guided radiofrequency ablation was performed at the patient\u2019s request. The procedure was successful and led to a favorable clinical outcome. This case highlights a potential alternative treatment approach for patients with SG, particularly those for whom surgery may pose additional risks.<\/jats:p>","DOI":"10.3389\/fonc.2025.1651824","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:17:02Z","timestamp":1755083822000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Opportunities and challenges of radiofrequency ablation for substernal goiter: a case 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